Muscular fatigue in Duchenne muscular dystrophy

Khema R Sharma, M. A. Mynhier, R. G. Miller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We used a 4-minute sustained maximum voluntary contraction to investigate fatigability of the anterior tibial muscle in eight healthy boys and 11 boys with Duchenne muscular dystrophy (DMD) (ages 5 to 10 years). Before exercise, the force generation of dystrophic muscle and the compound muscle action potential amplitude were lower and half-relaxation time of the tetanus was longer in patients than in controls. During exercise, the decline in tetanic force and potentiation in twitch tension were similar in both groups. However, during exercise, there was less decline in maximum voluntary contraction and less added force in DMD patients, suggesting that there was less central fatigue in patients than in controls. Thus, patients with DMD and controls have similar intramuscular fatigability and excitation- contraction coupling, and central activation in patients is functioning as well as or better than in healthy controls.

Original languageEnglish
Pages (from-to)306-310
Number of pages5
JournalNeurology
Volume45
Issue number2
StatePublished - Jan 1 1995

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Muscle Fatigue
Duchenne Muscular Dystrophy
Exercise
Excitation Contraction Coupling
Muscles
Tetanus
Action Potentials
Fatigue
Skeletal Muscle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sharma, K. R., Mynhier, M. A., & Miller, R. G. (1995). Muscular fatigue in Duchenne muscular dystrophy. Neurology, 45(2), 306-310.

Muscular fatigue in Duchenne muscular dystrophy. / Sharma, Khema R; Mynhier, M. A.; Miller, R. G.

In: Neurology, Vol. 45, No. 2, 01.01.1995, p. 306-310.

Research output: Contribution to journalArticle

Sharma, KR, Mynhier, MA & Miller, RG 1995, 'Muscular fatigue in Duchenne muscular dystrophy', Neurology, vol. 45, no. 2, pp. 306-310.
Sharma KR, Mynhier MA, Miller RG. Muscular fatigue in Duchenne muscular dystrophy. Neurology. 1995 Jan 1;45(2):306-310.
Sharma, Khema R ; Mynhier, M. A. ; Miller, R. G. / Muscular fatigue in Duchenne muscular dystrophy. In: Neurology. 1995 ; Vol. 45, No. 2. pp. 306-310.
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