Muscle fiber number in immobilization atrophy

D. D. Cardenas, W. C. Stolov, R. Hardy

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Eight Sprague-Dawley rats 10 to 12 weeks of age had one limb immobilized by plaster in knee flexion and ankle plantar flexion for 4 weeks. The soleus muscles from the control and immobilized limbs were excised and frozen. The technique that cross sections subsequently cut and stained would contain all the fibers extending from the origin to the insertion aponeuroses. The total number of muscle fibers per muscle was counted from 25 to 50 photomicrographs made for each muscle cross section. Paired comparisons of total muscle fibers in control and immobilized muscles revealed no significant differences. The total number of fibers in control and immobilized soleus muscles was 1812 ± 521 and 2930 ± 403, respectively. Therefore, muscle fiber loss does not occur in disuse atrophy produced by external immobilization as has been reported.

Original languageEnglish
Pages (from-to)423-426
Number of pages4
JournalArchives of Physical Medicine and Rehabilitation
Volume58
Issue number10
StatePublished - Dec 1 1977
Externally publishedYes

Fingerprint

Immobilization
Atrophy
Muscles
Skeletal Muscle
Extremities
Atrophic Muscular Disorders
Matched-Pair Analysis
Ankle
Sprague Dawley Rats
Knee

ASJC Scopus subject areas

  • Rehabilitation

Cite this

Cardenas, D. D., Stolov, W. C., & Hardy, R. (1977). Muscle fiber number in immobilization atrophy. Archives of Physical Medicine and Rehabilitation, 58(10), 423-426.

Muscle fiber number in immobilization atrophy. / Cardenas, D. D.; Stolov, W. C.; Hardy, R.

In: Archives of Physical Medicine and Rehabilitation, Vol. 58, No. 10, 01.12.1977, p. 423-426.

Research output: Contribution to journalArticle

Cardenas, DD, Stolov, WC & Hardy, R 1977, 'Muscle fiber number in immobilization atrophy', Archives of Physical Medicine and Rehabilitation, vol. 58, no. 10, pp. 423-426.
Cardenas DD, Stolov WC, Hardy R. Muscle fiber number in immobilization atrophy. Archives of Physical Medicine and Rehabilitation. 1977 Dec 1;58(10):423-426.
Cardenas, D. D. ; Stolov, W. C. ; Hardy, R. / Muscle fiber number in immobilization atrophy. In: Archives of Physical Medicine and Rehabilitation. 1977 ; Vol. 58, No. 10. pp. 423-426.
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