Murine skin as a target for melatonin bioregulation

Andrzej Slominski, Nikolaos Chassalevris, Joseph Mazurkiewicz, Marcus Maurer, Ralf Paus

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Abstract Specific binding sites for 3H‐melatonin were delected in membrane fractions prepared from C57 BL‐6 mouse skin, and were localized to the epidermis and the epithelial bulb of the hair follicle by in situ autoradiography. In skin organ culture, melatonin stimulated DNA synthesis by the epidermal keratinocytes at concentration 0.1‐10 nM, while at ≥1 μM it inhibited tyrosinase activity. We concluded that murine skin is a target for melatonin bioregulation.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalExperimental dermatology
Volume3
Issue number1
DOIs
StatePublished - Feb 1994
Externally publishedYes

Keywords

  • C57 BL‐6 mouse
  • keratinocytes
  • melatonin
  • skin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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