Murine motor neuron disease (the wobbler mouse). Degeneration and regeneration of the lower motor neuron

H. Mitsumoto, Walter G Bradley

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The study of the temporospatial pattern of lower motor neuronal degeneration in the wr/wr mouse demonstrated that the pathological changes started in the neuronal perikaryon in the spinal cord. Thus the wr/wr mouse suffers from a primary motor neuronopathy. Axonal pathology predominated at the level of the ventral root and suggested a focal proximal axonopathy. Microtubular segregation, neurofilamentous accumulation in the axon, and axonal or adaxonal vacuoles appeared to be closely related to subsequent axonal degeneration. Large myelinated fibres in the cervical ventral roots progressively degenerated and diminished in number with age. On the other hand, significant axonal regeneration coincided with the axonal degeneration in the cervical ventral roots. A dying-back type of degeneration and axonal atrophy were not present. This study demonstrated that a primary disease of the perikaryon may express itself as a focal proximal axonopathy characterized by axonal degeneration and attempted axonal regeneration.

Original languageEnglish
Pages (from-to)811-834
Number of pages24
JournalBrain
Volume105
Issue number4
StatePublished - Dec 1 1982
Externally publishedYes

Fingerprint

Motor Neuron Disease
Spinal Nerve Roots
Motor Neurons
Regeneration
Degeneration
motor neurons
Neurons
Mouse
Neuron
mice
Pathology
atrophy
axons
spinal cord
vacuoles
Roots
Vacuoles
Atrophy
Axons
Fibers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Clinical Neurology

Cite this

Murine motor neuron disease (the wobbler mouse). Degeneration and regeneration of the lower motor neuron. / Mitsumoto, H.; Bradley, Walter G.

In: Brain, Vol. 105, No. 4, 01.12.1982, p. 811-834.

Research output: Contribution to journalArticle

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