Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart

Konstantinos E. Hatzistergos; Joshua M. Hare

doi:10.1161/CIRCRESAHA.115.308061

Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit⁺ Lineages in the Heart

Konstantinos E. Hatzistergos, Joshua M. Hare

Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

After 2 recent genetic studies in mice addressing the developmental origins1 and regenerative activity of cardiac cKit⁺ cells,² 2 additional reports by Sultana et al3 and Liu et al4 provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.

Original language	English (US)
Pages (from-to)	382-387
Number of pages	6
Journal	Circulation research
Volume	118
Issue number	3
DOIs	https://doi.org/10.1161/CIRCRESAHA.115.308061
State	Published - 2016

Keywords

Cardiac
Cell differentiation
Cell- and tissue-based therapy
Coronary vessels
Endothelial cells
Myocytes

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Access to Document

10.1161/CIRCRESAHA.115.308061

Fingerprint Dive into the research topics of 'Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit<sup>+</sup> Lineages in the Heart'. Together they form a unique fingerprint.

Cite this

@article{023a0913ca89411cb2c80d4bcbb64987,

title = "Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart",

abstract = "After 2 recent genetic studies in mice addressing the developmental origins1 and regenerative activity of cardiac cKit+ cells,2 2 additional reports by Sultana et al3 and Liu et al4 provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.",

keywords = "Cardiac, Cell differentiation, Cell- and tissue-based therapy, Coronary vessels, Endothelial cells, Myocytes",

author = "Hatzistergos, {Konstantinos E.} and Hare, {Joshua M.}",

year = "2016",

doi = "10.1161/CIRCRESAHA.115.308061",

language = "English (US)",

volume = "118",

pages = "382--387",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Murine Models Demonstrate Distinct Vasculogenic and Cardiomyogenic cKit+ Lineages in the Heart

AU - Hatzistergos, Konstantinos E.

AU - Hare, Joshua M.

PY - 2016

Y1 - 2016

N2 - After 2 recent genetic studies in mice addressing the developmental origins1 and regenerative activity of cardiac cKit+ cells,2 2 additional reports by Sultana et al3 and Liu et al4 provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.

AB - After 2 recent genetic studies in mice addressing the developmental origins1 and regenerative activity of cardiac cKit+ cells,2 2 additional reports by Sultana et al3 and Liu et al4 provide further information on the expression of cKit in the embryonic and adult hearts. Here, we synthesize the findings from the 4 distinct cKit models to gain insights into the biology of this important cell type.

KW - Cardiac

KW - Cell differentiation

KW - Cell- and tissue-based therapy

KW - Coronary vessels

KW - Endothelial cells

KW - Myocytes

UR - http://www.scopus.com/inward/record.url?scp=84958554676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84958554676&partnerID=8YFLogxK

U2 - 10.1161/CIRCRESAHA.115.308061

DO - 10.1161/CIRCRESAHA.115.308061

M3 - Article

C2 - 26846638

AN - SCOPUS:84958554676

VL - 118

SP - 382

EP - 387

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 3

ER -