Murine isoforms of retinoic acid receptor γ with specific patterns of expression

P. Kastner, A. Krust, C. Mendelsohn, J. M. Garnier, A. Zelent, P. Leroy, A. Staub, P. Chambon

Research output: Contribution to journalArticle

258 Scopus citations

Abstract

We have characterized seven murine retinoic acid receptor γ cDNA isoforms (mRAR-γ1 to -γ7) generated by alternative splicing of at least seven exons. These isoforms differ from one another in their 5' untranslated region and in two cases (mRAR-γ1 and -γ2) differ in their N-terminal A region, which is known to be important for differential transactivation by other nuclear receptors. mRAR-γ1 and -γ2, the predominant isoforms, are differentially expressed in adult tissues and during embryogenesis. Most notably, skin contains almost exclusively mRAR-γ1 transcripts. The conservation of the RAR-γ isoforms from mouse to human together with their patterns of expression suggests that they perform specific functions, which may account for the pleiotropic effect of retinoic acid in embryogenesis and development.

Original languageEnglish (US)
Pages (from-to)2700-2704
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume87
Issue number7
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Murine isoforms of retinoic acid receptor γ with specific patterns of expression'. Together they form a unique fingerprint.

  • Cite this

    Kastner, P., Krust, A., Mendelsohn, C., Garnier, J. M., Zelent, A., Leroy, P., Staub, A., & Chambon, P. (1990). Murine isoforms of retinoic acid receptor γ with specific patterns of expression. Proceedings of the National Academy of Sciences of the United States of America, 87(7), 2700-2704. https://doi.org/10.1073/pnas.87.7.2700