Murine b7-2, an alternative ctla4 counter-receptor that costimulates t cell proliferation and interleukin 2 production

Gordon J. Freeman, Frank Borriello, Richard J. Hodes, Hans Reiser, John G. Gribben, Judy W. Ng, Jinny Kim, John M. Goldberg, Karen Hathcock, Gloria Laszlo, Lisa A. Lombard, Sophia Wang, Gary S. Gray, Lee M. Nadler, Arlene H. Sharpe

Research output: Contribution to journalArticle

336 Scopus citations

Abstract

The B7-1 molecule, expressed on antigen presenting cells (APC), provides a crucial costimulatory signal for T cell activation. Recent studies demonstrate the existence of alternative, non-B7-1 CTLA4 counter-receptors in mice and humans. Here, we describe the molecular cloning and demonstrate costimulatory function of the murine B7-2 (mB7-2) gene. Murine B7-2 cDNA encodes a member of the Ig supergene family that binds CTLA4-Ig and stains with the GL1 but not anti-mB7-1 mAb. Murine B7-2 costimulates the proliferation and interleukin 2 production of CD4+ T cells and this costimulation can be inhibited by either CTLA4-Ig or GL1 mAb. Identification of the B7-2 molecule will permit further manipulation of the B7:CD28/CTLA4 costimulatory pathway which has been shown to be involved in the prevention of tolerance, induction of tumor immunity, and most recently, in the pathogenesis of autoimmunity.

Original languageEnglish (US)
Pages (from-to)2185-2192
Number of pages8
JournalJournal of Experimental Medicine
Volume178
Issue number6
DOIs
StatePublished - Dec 1 1993

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Freeman, G. J., Borriello, F., Hodes, R. J., Reiser, H., Gribben, J. G., Ng, J. W., Kim, J., Goldberg, J. M., Hathcock, K., Laszlo, G., Lombard, L. A., Wang, S., Gray, G. S., Nadler, L. M., & Sharpe, A. H. (1993). Murine b7-2, an alternative ctla4 counter-receptor that costimulates t cell proliferation and interleukin 2 production. Journal of Experimental Medicine, 178(6), 2185-2192. https://doi.org/10.1084/jem.178.6.2185