Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis

Michael W. Weiner, Andrew Maudsley, Norbert Schuff, Brian J. Soher, Peter Vermathen, George Fein, Kenneth Laxer

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3337
DOIs
StatePublished - Dec 1 1998
Externally publishedYes
EventMedical Imaging 1998: Physiology and Function from Multidimensional Images - San Diego, CA, United States
Duration: Feb 22 1998Feb 23 1998

Keywords

  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Brain
  • Epilepsy
  • K -space
  • Magnetic resonance spectroscopic imaging
  • Magnetic resonance spectroscopy
  • MRI
  • Parametric spectral analysis
  • Segmentation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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