Abstract
Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | E.A. Hoffman |
| Pages | 203-209 |
| Number of pages | 7 |
| Volume | 3337 |
| DOIs | |
| State | Published - 1998 |
| Externally published | Yes |
| Event | Medical Imaging 1998: Physiology and Function from Multidimensional Images - San Diego, CA, United States Duration: Feb 22 1998 → Feb 23 1998 |
Other
| Other | Medical Imaging 1998: Physiology and Function from Multidimensional Images |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 2/22/98 → 2/23/98 |
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Keywords
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Brain
- Epilepsy
- K -space
- Magnetic resonance spectroscopic imaging
- Magnetic resonance spectroscopy
- MRI
- Parametric spectral analysis
- Segmentation
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
Multislice 1H magnetic resonance spectroscopic imaging : Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. / Weiner, Michael W.; Maudsley, Andrew A; Schuff, Norbert; Soher, Brian J.; Vermathen, Peter; Fein, George; Laxer, Kenneth.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / E.A. Hoffman. Vol. 3337 1998. p. 203-209.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Multislice 1H magnetic resonance spectroscopic imaging
T2 - Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis
AU - Weiner, Michael W.
AU - Maudsley, Andrew A
AU - Schuff, Norbert
AU - Soher, Brian J.
AU - Vermathen, Peter
AU - Fein, George
AU - Laxer, Kenneth
PY - 1998
Y1 - 1998
N2 - Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.
AB - Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.
KW - Alzheimer's disease
KW - Amyotrophic lateral sclerosis
KW - Brain
KW - Epilepsy
KW - K -space
KW - Magnetic resonance spectroscopic imaging
KW - Magnetic resonance spectroscopy
KW - MRI
KW - Parametric spectral analysis
KW - Segmentation
UR - http://www.scopus.com/inward/record.url?scp=0032401645&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032401645&partnerID=8YFLogxK
U2 - 10.1117/12.312565
DO - 10.1117/12.312565
M3 - Conference contribution
VL - 3337
SP - 203
EP - 209
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Hoffman, E.A.
ER -