Multislice 1H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis

Michael W. Weiner; Andrew Maudsley; Norbert Schuff; Brian J. Soher; Peter Vermathen; George Fein; Kenneth Laxer

doi:10.1117/12.312565

Multislice ¹H magnetic resonance spectroscopic imaging: Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis

Michael W. Weiner, Andrew Maudsley, Norbert Schuff, Brian J. Soher, Peter Vermathen, George Fein, Kenneth Laxer

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.

Original language	English (US)
Pages (from-to)	203-209
Number of pages	7
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	3337
DOIs	https://doi.org/10.1117/12.312565
State	Published - Dec 1 1998
Externally published	Yes
Event	Medical Imaging 1998: Physiology and Function from Multidimensional Images - San Diego, CA, United States Duration: Feb 22 1998 → Feb 23 1998

Keywords

Alzheimer's disease
Amyotrophic lateral sclerosis
Brain
Epilepsy
K -space
Magnetic resonance spectroscopic imaging
Magnetic resonance spectroscopy
MRI
Parametric spectral analysis
Segmentation

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.312565

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Multislice ¹H magnetic resonance spectroscopic imaging : Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. / Weiner, Michael W.; Maudsley, Andrew; Schuff, Norbert; Soher, Brian J.; Vermathen, Peter; Fein, George; Laxer, Kenneth.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 3337, 01.12.1998, p. 203-209.

Research output: Contribution to journal › Conference article › peer-review

Weiner, Michael W. ; Maudsley, Andrew ; Schuff, Norbert ; Soher, Brian J. ; Vermathen, Peter ; Fein, George ; Laxer, Kenneth. / Multislice ¹H magnetic resonance spectroscopic imaging : Assessment of Epilepsy, Alzheimer's disease, and Amyotrophic lateral sclerosis. In: Proceedings of SPIE - The International Society for Optical Engineering. 1998 ; Vol. 3337. pp. 203-209.

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abstract = "Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.",

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AU - Weiner, Michael W.

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AU - Soher, Brian J.

AU - Vermathen, Peter

AU - Fein, George

AU - Laxer, Kenneth

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KW - Amyotrophic lateral sclerosis

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