Abstract
Proton magnetic resonance spectroscopic imaging (1H MRSI) with volume pre-selection (i.e. by PRESS) or multislice 1H MRSI was used to investigate changes in brain metabolites in Alzheimer's disease, epilepsy, and amyotrophic lateral sclerosis. Examples of results from several ongoing clinical studies are provided. Multislice 1H MRSI of the human brain, without volume pre-selection offers considerable advantages over previously available techniques. Furthermore, MRI tissue segmentation and completely automated spectra curve fitting greatly facilitate quantitative data analysis. Future efforts will be devoted to obtaining full brain coverage and data acquisition at short spin echo times (TE< 30 ms) for the detection of metabolites with short T2 relaxation times.
Original language | English (US) |
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Pages (from-to) | 203-209 |
Number of pages | 7 |
Journal | Proceedings of SPIE - The International Society for Optical Engineering |
Volume | 3337 |
DOIs | |
State | Published - Dec 1 1998 |
Externally published | Yes |
Event | Medical Imaging 1998: Physiology and Function from Multidimensional Images - San Diego, CA, United States Duration: Feb 22 1998 → Feb 23 1998 |
Keywords
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Brain
- Epilepsy
- K -space
- Magnetic resonance spectroscopic imaging
- Magnetic resonance spectroscopy
- MRI
- Parametric spectral analysis
- Segmentation
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Computer Science Applications
- Applied Mathematics
- Electrical and Electronic Engineering