Abstract
We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds.
| Original language | English |
|---|---|
| Pages (from-to) | 1546-1552 |
| Number of pages | 7 |
| Journal | Neurology |
| Volume | 40 |
| Issue number | 10 |
| State | Published - Oct 1 1990 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Multiple sclerosis sibling pairs : Clustered onset and familial predisposition. / Doolittle, T. H.; Myers, R. H.; Lehrich, J. R.; Birnbaum, G.; Sheremata, William; Franklin, G. M.; Nelson, L. M.; Hauser, S. L.
In: Neurology, Vol. 40, No. 10, 01.10.1990, p. 1546-1552.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple sclerosis sibling pairs
T2 - Clustered onset and familial predisposition
AU - Doolittle, T. H.
AU - Myers, R. H.
AU - Lehrich, J. R.
AU - Birnbaum, G.
AU - Sheremata, William
AU - Franklin, G. M.
AU - Nelson, L. M.
AU - Hauser, S. L.
PY - 1990/10/1
Y1 - 1990/10/1
N2 - We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds.
AB - We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025089312&partnerID=8YFLogxK
M3 - Article
C2 - 2215946
AN - SCOPUS:0025089312
VL - 40
SP - 1546
EP - 1552
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 10
ER -