Multiple sclerosis sibling pairs: Clustered onset and familial predisposition

T. H. Doolittle, R. H. Myers, J. R. Lehrich, G. Birnbaum, William Sheremata, G. M. Franklin, L. M. Nelson, S. L. Hauser

Research output: Contribution to journalArticle

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Abstract

We evaluated 48 relapsing-remitting multiple sclerosis (R/R MS) sibling pairs derived from 44 families for age and date of onset of MS symptoms, clinical course, and family history of MS. Age- and sex-matched R/R MS clinic patients provided a statistical comparison group. The age of onset tended to cluster within multiplex families. The initial symptom of MS occurred within 5 years of age in 30/48 sibling pairs compared with 16/48 controls. A positive family history of MS (other than siblings) was present in 43% of the multiplex families compared with 20% among simplex controls. In 1st-, 2nd-, and 3rd-degree relatives who had lived into the age at risk, 22/1,134 family members of multiplex sibling pairs had probable or definite MS compared with 10/1,215 control family members. Age of onset clustering in siblings concordant for R/R MS and an increased risk of MS in other family members suggest that factors influencing disease onset may be in part inherited in these kindreds.

Original languageEnglish
Pages (from-to)1546-1552
Number of pages7
JournalNeurology
Volume40
Issue number10
StatePublished - Oct 1 1990

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Multiple Sclerosis
Siblings
Relapsing-Remitting Multiple Sclerosis
Age of Onset
Cluster Analysis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Doolittle, T. H., Myers, R. H., Lehrich, J. R., Birnbaum, G., Sheremata, W., Franklin, G. M., ... Hauser, S. L. (1990). Multiple sclerosis sibling pairs: Clustered onset and familial predisposition. Neurology, 40(10), 1546-1552.

Multiple sclerosis sibling pairs : Clustered onset and familial predisposition. / Doolittle, T. H.; Myers, R. H.; Lehrich, J. R.; Birnbaum, G.; Sheremata, William; Franklin, G. M.; Nelson, L. M.; Hauser, S. L.

In: Neurology, Vol. 40, No. 10, 01.10.1990, p. 1546-1552.

Research output: Contribution to journalArticle

Doolittle, TH, Myers, RH, Lehrich, JR, Birnbaum, G, Sheremata, W, Franklin, GM, Nelson, LM & Hauser, SL 1990, 'Multiple sclerosis sibling pairs: Clustered onset and familial predisposition', Neurology, vol. 40, no. 10, pp. 1546-1552.
Doolittle TH, Myers RH, Lehrich JR, Birnbaum G, Sheremata W, Franklin GM et al. Multiple sclerosis sibling pairs: Clustered onset and familial predisposition. Neurology. 1990 Oct 1;40(10):1546-1552.
Doolittle, T. H. ; Myers, R. H. ; Lehrich, J. R. ; Birnbaum, G. ; Sheremata, William ; Franklin, G. M. ; Nelson, L. M. ; Hauser, S. L. / Multiple sclerosis sibling pairs : Clustered onset and familial predisposition. In: Neurology. 1990 ; Vol. 40, No. 10. pp. 1546-1552.
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