Multiple sclerosis: Sensitization to a myelin basic protein fragment (peptide T) encephalitogenic to primates. A preliminary report

William Sheremata, E. H. Eylar, J. B R Cosgrove

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Myelin basic A1 protein is the sole antigen of the central nervous system capable of inducing experimental allergic encephalitis (EAE), but sensitization with peptide fragments of the molecule may also induce disease. Using the macrophage migration inhibition factor (MIF) assay we have compared sensitization to portions of the molecule active in inducing EAE in monkeys with results obtained concomitantly using the intact protein. Cellular sensitization to human myelin A1 protein, peptide L (residues 1-116), peptide T (residues 117-170), and peptide Y (residues 154-170) was studied using the Thor-Rocklin MIF assay system. Lymphocytes of 10 normal subjects, 10 multiple sclerosis patients 0-3 weeks after onset, 10 4 weeks to 3 months after and 10 6 months or longer after onset of an acute exacerbation were assayed. Results of the investigation reveal evidence of cellular sensitization to myelin basic protein and encephalitogenic peptide T occurring during attacks of multiple sclerosis. Peptide L, relatively nonencephalitogenic to primates, failed to induce a significant lymphocyte response, whereas peptide Y which is encephalitogenic gave irregular results.

Original languageEnglish
Pages (from-to)255-263
Number of pages9
JournalJournal of the Neurological Sciences
Volume32
Issue number2
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

Fingerprint

Peptide T
Myelin Basic Protein
Encephalitis
Primates
Multiple Sclerosis
Lymphocytes
Macrophage Migration-Inhibitory Factors
Myelin Proteins
Peptides
Peptide Fragments
Haplorhini
Central Nervous System
Antigens
Proteins
peptide L

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Multiple sclerosis : Sensitization to a myelin basic protein fragment (peptide T) encephalitogenic to primates. A preliminary report. / Sheremata, William; Eylar, E. H.; Cosgrove, J. B R.

In: Journal of the Neurological Sciences, Vol. 32, No. 2, 01.01.1977, p. 255-263.

Research output: Contribution to journalArticle

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