TY - JOUR
T1 - Multiple sclerosis-like illness occurring with human immunodeficiency virus infection
AU - Berger, J. R.
AU - Sheremata, W. A.
AU - Resnick, L.
AU - Atherton, S.
AU - Fletcher, M. A.
AU - Norenberg, M.
PY - 1989/3
Y1 - 1989/3
N2 - We describe seven men with a neurologic disease clinically indistinguishable from multiple sclerosis occurring in association with seropositivity for the human immunodeficiency virus, type 1 (HIV-1). Histopathology of the CNS obtained in three patients (2 by brain biopsy, 1 at autopsy) was consistent with MS. The neurologic symptoms preceded the onset of clinically evident immunosuppression in all patients. In three men, HIV-1 seropositivity was demonstrated concomitantly or within 3 months of the onset of their neurologic disease. In the others, features of MS preceded the demonstration of HIV-1 seropositivity by 41 months, 59 months, 11 years, and 18 years, respectively. Despite the superimposition of varying degrees of cellular immunodeficiency associated with HIV-1 infection, six of these men continued to experience relapsing neurologic symptoms.
AB - We describe seven men with a neurologic disease clinically indistinguishable from multiple sclerosis occurring in association with seropositivity for the human immunodeficiency virus, type 1 (HIV-1). Histopathology of the CNS obtained in three patients (2 by brain biopsy, 1 at autopsy) was consistent with MS. The neurologic symptoms preceded the onset of clinically evident immunosuppression in all patients. In three men, HIV-1 seropositivity was demonstrated concomitantly or within 3 months of the onset of their neurologic disease. In the others, features of MS preceded the demonstration of HIV-1 seropositivity by 41 months, 59 months, 11 years, and 18 years, respectively. Despite the superimposition of varying degrees of cellular immunodeficiency associated with HIV-1 infection, six of these men continued to experience relapsing neurologic symptoms.
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U2 - 10.1212/wnl.39.3.324
DO - 10.1212/wnl.39.3.324
M3 - Article
C2 - 2927638
AN - SCOPUS:0024556007
VL - 39
SP - 324
EP - 329
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 3
ER -