Multiple sclerosis as a vascular disease

Alireza Minagar, Wenche Jy, Joaquin J Jimenez, J. Steven Alexander

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Multiple sclerosis (MS) has traditionally been viewed and researched as an immune-mediated disease with principal emphasis on the role of activated inflammatory cells, oligodendrocytes and astrocytes in its pathogenesis. Abnormalities of cerebral endothelial cells (CECs) is an under explored facet of MS pathogenesis and vascular abnormalities play a crucial role in formation of the MS lesions and disease progress, at least in the initial stages of disease. This review will focus on MS as a central nervous system (CNS) disease with a strong vascular constituent and examines abnormalities within CECs in MS and their role in the loss of blood-brain barrier and transendothelial migration of activated leukocytes into the CNS. One goal of this paper is to persuade and promote research on the endothelial abnormalities in pathogenesis of MS and to exploit existing knowledge on endothelial injury. A deeper understanding of endothelial pathophysiology in MS may help develop effective treatments through stabilization of endothelial function, translating into delay or arrest of MS disease onset and disability in MS patients.

Original languageEnglish
Pages (from-to)230-235
Number of pages6
JournalNeurological Research
Volume28
Issue number3
DOIs
StatePublished - Apr 1 2006

Fingerprint

Vascular Diseases
Multiple Sclerosis
Blood Vessels
Endothelial Cells
Transendothelial and Transepithelial Migration
Central Nervous System Diseases
Immune System Diseases
Oligodendroglia
Blood-Brain Barrier
Astrocytes
Leukocytes
Central Nervous System
Wounds and Injuries
Research

Keywords

  • Blood-brain barrier
  • Cerebral endothelial cells
  • Multiple sclerosis
  • Transendothelial migration

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Multiple sclerosis as a vascular disease. / Minagar, Alireza; Jy, Wenche; Jimenez, Joaquin J; Alexander, J. Steven.

In: Neurological Research, Vol. 28, No. 3, 01.04.2006, p. 230-235.

Research output: Contribution to journalArticle

Minagar, Alireza ; Jy, Wenche ; Jimenez, Joaquin J ; Alexander, J. Steven. / Multiple sclerosis as a vascular disease. In: Neurological Research. 2006 ; Vol. 28, No. 3. pp. 230-235.
@article{9bcb4f83092140529d758501a2d83e3e,
title = "Multiple sclerosis as a vascular disease",
abstract = "Multiple sclerosis (MS) has traditionally been viewed and researched as an immune-mediated disease with principal emphasis on the role of activated inflammatory cells, oligodendrocytes and astrocytes in its pathogenesis. Abnormalities of cerebral endothelial cells (CECs) is an under explored facet of MS pathogenesis and vascular abnormalities play a crucial role in formation of the MS lesions and disease progress, at least in the initial stages of disease. This review will focus on MS as a central nervous system (CNS) disease with a strong vascular constituent and examines abnormalities within CECs in MS and their role in the loss of blood-brain barrier and transendothelial migration of activated leukocytes into the CNS. One goal of this paper is to persuade and promote research on the endothelial abnormalities in pathogenesis of MS and to exploit existing knowledge on endothelial injury. A deeper understanding of endothelial pathophysiology in MS may help develop effective treatments through stabilization of endothelial function, translating into delay or arrest of MS disease onset and disability in MS patients.",
keywords = "Blood-brain barrier, Cerebral endothelial cells, Multiple sclerosis, Transendothelial migration",
author = "Alireza Minagar and Wenche Jy and Jimenez, {Joaquin J} and Alexander, {J. Steven}",
year = "2006",
month = "4",
day = "1",
doi = "10.1179/016164106X98080",
language = "English",
volume = "28",
pages = "230--235",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "3",

}

TY - JOUR

T1 - Multiple sclerosis as a vascular disease

AU - Minagar, Alireza

AU - Jy, Wenche

AU - Jimenez, Joaquin J

AU - Alexander, J. Steven

PY - 2006/4/1

Y1 - 2006/4/1

N2 - Multiple sclerosis (MS) has traditionally been viewed and researched as an immune-mediated disease with principal emphasis on the role of activated inflammatory cells, oligodendrocytes and astrocytes in its pathogenesis. Abnormalities of cerebral endothelial cells (CECs) is an under explored facet of MS pathogenesis and vascular abnormalities play a crucial role in formation of the MS lesions and disease progress, at least in the initial stages of disease. This review will focus on MS as a central nervous system (CNS) disease with a strong vascular constituent and examines abnormalities within CECs in MS and their role in the loss of blood-brain barrier and transendothelial migration of activated leukocytes into the CNS. One goal of this paper is to persuade and promote research on the endothelial abnormalities in pathogenesis of MS and to exploit existing knowledge on endothelial injury. A deeper understanding of endothelial pathophysiology in MS may help develop effective treatments through stabilization of endothelial function, translating into delay or arrest of MS disease onset and disability in MS patients.

AB - Multiple sclerosis (MS) has traditionally been viewed and researched as an immune-mediated disease with principal emphasis on the role of activated inflammatory cells, oligodendrocytes and astrocytes in its pathogenesis. Abnormalities of cerebral endothelial cells (CECs) is an under explored facet of MS pathogenesis and vascular abnormalities play a crucial role in formation of the MS lesions and disease progress, at least in the initial stages of disease. This review will focus on MS as a central nervous system (CNS) disease with a strong vascular constituent and examines abnormalities within CECs in MS and their role in the loss of blood-brain barrier and transendothelial migration of activated leukocytes into the CNS. One goal of this paper is to persuade and promote research on the endothelial abnormalities in pathogenesis of MS and to exploit existing knowledge on endothelial injury. A deeper understanding of endothelial pathophysiology in MS may help develop effective treatments through stabilization of endothelial function, translating into delay or arrest of MS disease onset and disability in MS patients.

KW - Blood-brain barrier

KW - Cerebral endothelial cells

KW - Multiple sclerosis

KW - Transendothelial migration

UR - http://www.scopus.com/inward/record.url?scp=33646818945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646818945&partnerID=8YFLogxK

U2 - 10.1179/016164106X98080

DO - 10.1179/016164106X98080

M3 - Article

C2 - 16687046

AN - SCOPUS:33646818945

VL - 28

SP - 230

EP - 235

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 3

ER -