Multiple sclerosis and cell-mediated hypersensitivity to myelin A1 protein

William Sheremata, J. B R Cosgrove, E. H. Eylar

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Cellular hypersensitivity to myelin basic (A1) protein was evaluated using the MIF assay in 246 subjects. Of 100 with multiple sclerosis positive results are seen in relationship to acute exacerbations of illness. Normal control subjects gave a mean value of 100 ± 9% whereas patients studied within 4 weeks of onset of illness gave a result of 59 ± 12.5%. A convalescent group studied between 5 and 12 weeks after an attack gave results of 86 ± 22.2%. A chronic group gave a mean of 91 ± 8.2%. Positive values were also seen in a number of other patients with central or peripheral nervous system disease especially those with "autoimmune disease". However, results of this study clearly establish a temporal relationship between in vitro evidence of hypersensitivity to A1 protein and clinical expression of disease.

Original languageEnglish
Pages (from-to)413-425
Number of pages13
JournalJournal of the Neurological Sciences
Volume27
Issue number4
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

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Myelin Proteins
Multiple Sclerosis
Hypersensitivity
Myelin Basic Protein
Central Nervous System Diseases
Peripheral Nervous System Diseases
Autoimmune Diseases
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Multiple sclerosis and cell-mediated hypersensitivity to myelin A1 protein. / Sheremata, William; Cosgrove, J. B R; Eylar, E. H.

In: Journal of the Neurological Sciences, Vol. 27, No. 4, 01.01.1976, p. 413-425.

Research output: Contribution to journalArticle

Sheremata, William ; Cosgrove, J. B R ; Eylar, E. H. / Multiple sclerosis and cell-mediated hypersensitivity to myelin A1 protein. In: Journal of the Neurological Sciences. 1976 ; Vol. 27, No. 4. pp. 413-425.
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