Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites

Yossef Itzhak, Kenneth A. Bonnet, Janice Groth, Jacob M. Hiller, Eric J. Simon

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.

Original languageEnglish (US)
Pages (from-to)1363-1366
Number of pages4
JournalLife Sciences
Volume31
Issue number12-13
DOIs
StatePublished - Sep 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Itzhak, Y., Bonnet, K. A., Groth, J., Hiller, J. M., & Simon, E. J. (1982). Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites. Life Sciences, 31(12-13), 1363-1366. https://doi.org/10.1016/0024-3205(82)90382-4