Abstract
Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1363-1366 |
| Number of pages | 4 |
| Journal | Life Sciences |
| Volume | 31 |
| Issue number | 12-13 |
| DOIs | |
| State | Published - Sep 1982 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Itzhak, Y., Bonnet, K. A., Groth, J., Hiller, J. M., & Simon, E. J. (1982). Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites. Life Sciences, 31(12-13), 1363-1366. https://doi.org/10.1016/0024-3205(82)90382-4