Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites

Yossef Itzhak; Kenneth A. Bonnet; Janice Groth; Jacob M. Hiller; Eric J. Simon

doi:10.1016/0024-3205(82)90382-4

Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites

Yossef Itzhak, Kenneth A. Bonnet, Janice Groth, Jacob M. Hiller, Eric J. Simon

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.

Original language	English (US)
Pages (from-to)	1363-1366
Number of pages	4
Journal	Life Sciences
Volume	31
Issue number	12-13
DOIs	https://doi.org/10.1016/0024-3205(82)90382-4
State	Published - Sep 1982

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.",

author = "Yossef Itzhak and Bonnet, {Kenneth A.} and Janice Groth and Hiller, {Jacob M.} and Simon, {Eric J.}",

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T2 - Evidence for κ and σ sites

AU - Itzhak, Yossef

AU - Bonnet, Kenneth A.

AU - Groth, Janice

AU - Hiller, Jacob M.

AU - Simon, Eric J.

PY - 1982/9

Y1 - 1982/9

N2 - Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.

AB - Evidence is presented for the presence of opiate binding sites with a preference for benzomorphans in seven regions of the human brain. The highest concentration of these sites was found in the hypothalamus and the lowest level in the thalamus. By utilizing the phencyclidine derivative, 3-hydroxyphencyclidine, we have obtained data suggesting that these benzomorphan binding sites may be a mixture of κ and σ sub-types of opiate receptors.

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Multiple opiate binding sites in human brain regions: Evidence for κ and σ sites

Abstract

ASJC Scopus subject areas

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