Abstract
We report a 26-year-old woman with congenital hepatic fibrosis (CHFib), adult polycystic kidney disease, type II diabetes mellitus, and von Willebrand disease, who despite persistent advice to the contrary because of severe portal hypertension, had 5 pregnancies delivering 6 healthy infants over 8 yr. During this time, she experienced several episodes of esophageal variceal bleeding and severe ascites with persistently normal liver and renal function. CHFib is one of the prototypes of portal hypertension with preserved hepatocellular function. Although pregnancy is ill-advised in most women with portal hypertension and particularly with severe manifestations, this report illustrates the importance of preserved hepatocellular function for the outcome of pregnancy in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 2359-2361 |
| Number of pages | 3 |
| Journal | American Journal of Gastroenterology |
| Volume | 100 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 1 2005 |
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ASJC Scopus subject areas
- Gastroenterology
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Multiple normal deliveries in a woman with severe portal hypertension due to congenital hepatic fibrosis : The importance of preserved hepatocellular function. / Mindikoglu, Ayse L.; Regev, Arie; O'Sullivan, Mary J.; Schiff, Eugene R.
In: American Journal of Gastroenterology, Vol. 100, No. 10, 01.10.2005, p. 2359-2361.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Multiple normal deliveries in a woman with severe portal hypertension due to congenital hepatic fibrosis
T2 - The importance of preserved hepatocellular function
AU - Mindikoglu, Ayse L.
AU - Regev, Arie
AU - O'Sullivan, Mary J.
AU - Schiff, Eugene R
PY - 2005/10/1
Y1 - 2005/10/1
N2 - We report a 26-year-old woman with congenital hepatic fibrosis (CHFib), adult polycystic kidney disease, type II diabetes mellitus, and von Willebrand disease, who despite persistent advice to the contrary because of severe portal hypertension, had 5 pregnancies delivering 6 healthy infants over 8 yr. During this time, she experienced several episodes of esophageal variceal bleeding and severe ascites with persistently normal liver and renal function. CHFib is one of the prototypes of portal hypertension with preserved hepatocellular function. Although pregnancy is ill-advised in most women with portal hypertension and particularly with severe manifestations, this report illustrates the importance of preserved hepatocellular function for the outcome of pregnancy in these patients.
AB - We report a 26-year-old woman with congenital hepatic fibrosis (CHFib), adult polycystic kidney disease, type II diabetes mellitus, and von Willebrand disease, who despite persistent advice to the contrary because of severe portal hypertension, had 5 pregnancies delivering 6 healthy infants over 8 yr. During this time, she experienced several episodes of esophageal variceal bleeding and severe ascites with persistently normal liver and renal function. CHFib is one of the prototypes of portal hypertension with preserved hepatocellular function. Although pregnancy is ill-advised in most women with portal hypertension and particularly with severe manifestations, this report illustrates the importance of preserved hepatocellular function for the outcome of pregnancy in these patients.
UR - http://www.scopus.com/inward/record.url?scp=27744457053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744457053&partnerID=8YFLogxK
U2 - 10.1111/j.1572-0241.2005.00255.x
DO - 10.1111/j.1572-0241.2005.00255.x
M3 - Article
C2 - 16181390
AN - SCOPUS:27744457053
VL - 100
SP - 2359
EP - 2361
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 10
ER -