Multiple myeloma, chronic lymphocytic leukaemia and associated precursor diseases

Ola Landgren, Robert A. Kyle

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Multiple myeloma and chronic lymphocytic leukaemia share common biological and clinical features including the presence of defined precursor conditions (monoclonal gammopathy of undetermined significance and monoclonal B-cell lymphocytosis respectively). Here, we discuss evidence from the literature on the potential aetiological roles for genetic and chronic immune stimulatory factors on the pathway from precursor to malignancy. Also, we speculate on the relationship between precursor and malignancy and talk about future directions and gaps in the literature.

Original languageEnglish (US)
Pages (from-to)717-723
Number of pages7
JournalBritish Journal of Haematology
Volume139
Issue number5
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Chronic lymphocytic leukaemia
  • Monoclonal B-cell lymphocytosis
  • Monoclonal gammopathy of undetermined significance
  • Multiple myeloma
  • Precursor disease

ASJC Scopus subject areas

  • Hematology

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