Abstract
Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.
| Original language | English |
|---|---|
| Pages (from-to) | 306-312 |
| Number of pages | 7 |
| Journal | Clinical Biochemistry |
| Volume | 41 |
| Issue number | 4-5 |
| DOIs | |
| State | Published - Mar 1 2008 |
Fingerprint
Keywords
- Gene
- Haplotype
- Lipids
- Reverses cholesterol transport pathway
- Single nucleotide polymorphisms
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics. / Liao, Yi Chu; Lin, Hsiu Fen; Rundek, Tatjana; Cheng, Rong; Hsi, Edward; Sacco, Ralph L; Juo, Suh Hang Hank.
In: Clinical Biochemistry, Vol. 41, No. 4-5, 01.03.2008, p. 306-312.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics
AU - Liao, Yi Chu
AU - Lin, Hsiu Fen
AU - Rundek, Tatjana
AU - Cheng, Rong
AU - Hsi, Edward
AU - Sacco, Ralph L
AU - Juo, Suh Hang Hank
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.
AB - Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.
KW - Gene
KW - Haplotype
KW - Lipids
KW - Reverses cholesterol transport pathway
KW - Single nucleotide polymorphisms
UR - http://www.scopus.com/inward/record.url?scp=39149114089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=39149114089&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2007.11.011
DO - 10.1016/j.clinbiochem.2007.11.011
M3 - Article
C2 - 18078817
AN - SCOPUS:39149114089
VL - 41
SP - 306
EP - 312
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 4-5
ER -