Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Yi Chu Liao; Hsiu Fen Lin; Tanja Rundek; Rong Cheng; Edward Hsi; Ralph L. Sacco; Suh Hang Hank Juo

doi:10.1016/j.clinbiochem.2007.11.011

Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Yi Chu Liao, Hsiu Fen Lin, Tanja Rundek, Rong Cheng, Edward Hsi, Ralph L. Sacco, Suh Hang Hank Juo

Neurology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

Original language	English (US)
Pages (from-to)	306-312
Number of pages	7
Journal	Clinical Biochemistry
Volume	41
Issue number	4-5
DOIs	https://doi.org/10.1016/j.clinbiochem.2007.11.011
State	Published - Mar 2008

Keywords

Gene
Haplotype
Lipids
Reverses cholesterol transport pathway
Single nucleotide polymorphisms

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2007.11.011

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title = "Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics",

abstract = "Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.",

keywords = "Gene, Haplotype, Lipids, Reverses cholesterol transport pathway, Single nucleotide polymorphisms",

author = "Liao, {Yi Chu} and Lin, {Hsiu Fen} and Tanja Rundek and Rong Cheng and Edward Hsi and Sacco, {Ralph L.} and Juo, {Suh Hang Hank}",

note = "Funding Information: This work was supported by grants from the National Institute of Neurological Disorders and Stroke (USA) R01 NS40807 (SHJ, TR, and RLS), RO1 NS047655 (SHJ, TR, RLS, and RC), RO1 NS29993 (RLS, TR), Irving General Clinical Research Center (2 M01 RR00645), and National Health Research Institutes (Taiwan) NHRI-Ex96-9607 (SHJ and YCL).",

year = "2008",

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doi = "10.1016/j.clinbiochem.2007.11.011",

language = "English (US)",

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pages = "306--312",

journal = "Clinical Biochemistry",

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AU - Liao, Yi Chu

AU - Lin, Hsiu Fen

AU - Rundek, Tanja

AU - Cheng, Rong

AU - Hsi, Edward

AU - Sacco, Ralph L.

AU - Juo, Suh Hang Hank

N1 - Funding Information: This work was supported by grants from the National Institute of Neurological Disorders and Stroke (USA) R01 NS40807 (SHJ, TR, and RLS), RO1 NS047655 (SHJ, TR, RLS, and RC), RO1 NS29993 (RLS, TR), Irving General Clinical Research Center (2 M01 RR00645), and National Health Research Institutes (Taiwan) NHRI-Ex96-9607 (SHJ and YCL).

PY - 2008/3

Y1 - 2008/3

N2 - Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

AB - Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

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Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Abstract

Keywords

ASJC Scopus subject areas

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