Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Yi Chu Liao, Hsiu Fen Lin, Tanja Rundek, Rong Cheng, Edward Hsi, Ralph L. Sacco, Suh Hang Hank Juo

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

Original languageEnglish (US)
Pages (from-to)306-312
Number of pages7
JournalClinical Biochemistry
Volume41
Issue number4-5
DOIs
StatePublished - Mar 2008

Keywords

  • Gene
  • Haplotype
  • Lipids
  • Reverses cholesterol transport pathway
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Clinical Biochemistry

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