Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics

Yi Chu Liao, Hsiu Fen Lin, Tatjana Rundek, Rong Cheng, Edward Hsi, Ralph L Sacco, Suh Hang Hank Juo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p < 0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7A1 genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalClinical Biochemistry
Volume41
Issue number4-5
DOIs
StatePublished - Mar 1 2008

Fingerprint

Hispanic Americans
Genes
Lipids
Plasmas
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
LDL Cholesterol
Triglycerides
Cholesterol
Apolipoproteins
Apolipoproteins B
Bile Acids and Salts
Cytochrome P-450 Enzyme System
Haplotypes
Peptides

Keywords

  • Gene
  • Haplotype
  • Lipids
  • Reverses cholesterol transport pathway
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics. / Liao, Yi Chu; Lin, Hsiu Fen; Rundek, Tatjana; Cheng, Rong; Hsi, Edward; Sacco, Ralph L; Juo, Suh Hang Hank.

In: Clinical Biochemistry, Vol. 41, No. 4-5, 01.03.2008, p. 306-312.

Research output: Contribution to journalArticle

Liao, Yi Chu ; Lin, Hsiu Fen ; Rundek, Tatjana ; Cheng, Rong ; Hsi, Edward ; Sacco, Ralph L ; Juo, Suh Hang Hank. / Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics. In: Clinical Biochemistry. 2008 ; Vol. 41, No. 4-5. pp. 306-312.
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