Multiple Endocrine Neoplasia Type IIa

A Case Report

Tossaporn Seeherunvong, Sunchai Churesigaew, Vichitra Hemsrichart

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The authors reported a twelve year and four-month old girl who had prolonged fever for 2 weeks. Physical examination revealed a painless enlarged thyroid gland with firm consistency. Hyperparathyroidism was suspected because of hypercalcemia, hypophosphatemia, high level of serum alkaline phosphatase, and decreased density of long bones. Thyroid scan showed a cold nodule of the left upper lobe which subsequently proved to be a medullary thyroid carcinoma by high serum thyrocalcitonin level and pathological examination. Her 24-hour urinary vanillyl mandelic acid was in the normal range, and abdominal ultrasonography demonstrated normal adrenal glands. Multiple endocrine neoplasia type IIa (MEN IIa) was diagnosed by medullary thyroid carcinoma and hyperparathyroidism. However, the fully developed syndrome is characterized by the combined occurrence of medullary thyroid carcinoma, primary hyperparathyroidism, and pheochromocytomas. This syndrome is a rare, complex, and potentially lethal disease so early recognition and family screening are very important.

Original languageEnglish
Pages (from-to)788-793
Number of pages6
JournalJournal of the Medical Association of Thailand
Volume81
Issue number10
StatePublished - Oct 1 1998
Externally publishedYes

Fingerprint

Multiple Endocrine Neoplasia Type 2a
Hyperparathyroidism
Thyroid Gland
Hypophosphatemia
Primary Hyperparathyroidism
Calcitonin
Hypercalcemia
Pheochromocytoma
Adrenal Glands
Serum
Bone Density
Physical Examination
Alkaline Phosphatase
Ultrasonography
Reference Values
Fever
Medullary Thyroid cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Multiple Endocrine Neoplasia Type IIa : A Case Report. / Seeherunvong, Tossaporn; Churesigaew, Sunchai; Hemsrichart, Vichitra.

In: Journal of the Medical Association of Thailand, Vol. 81, No. 10, 01.10.1998, p. 788-793.

Research output: Contribution to journalArticle

Seeherunvong, Tossaporn ; Churesigaew, Sunchai ; Hemsrichart, Vichitra. / Multiple Endocrine Neoplasia Type IIa : A Case Report. In: Journal of the Medical Association of Thailand. 1998 ; Vol. 81, No. 10. pp. 788-793.
@article{9c743db7350845f3a91f81452b2b7ec1,
title = "Multiple Endocrine Neoplasia Type IIa: A Case Report",
abstract = "The authors reported a twelve year and four-month old girl who had prolonged fever for 2 weeks. Physical examination revealed a painless enlarged thyroid gland with firm consistency. Hyperparathyroidism was suspected because of hypercalcemia, hypophosphatemia, high level of serum alkaline phosphatase, and decreased density of long bones. Thyroid scan showed a cold nodule of the left upper lobe which subsequently proved to be a medullary thyroid carcinoma by high serum thyrocalcitonin level and pathological examination. Her 24-hour urinary vanillyl mandelic acid was in the normal range, and abdominal ultrasonography demonstrated normal adrenal glands. Multiple endocrine neoplasia type IIa (MEN IIa) was diagnosed by medullary thyroid carcinoma and hyperparathyroidism. However, the fully developed syndrome is characterized by the combined occurrence of medullary thyroid carcinoma, primary hyperparathyroidism, and pheochromocytomas. This syndrome is a rare, complex, and potentially lethal disease so early recognition and family screening are very important.",
author = "Tossaporn Seeherunvong and Sunchai Churesigaew and Vichitra Hemsrichart",
year = "1998",
month = "10",
day = "1",
language = "English",
volume = "81",
pages = "788--793",
journal = "Journal of the Medical Association of Thailand",
issn = "0125-2208",
publisher = "Medical Association of Thailand",
number = "10",

}

TY - JOUR

T1 - Multiple Endocrine Neoplasia Type IIa

T2 - A Case Report

AU - Seeherunvong, Tossaporn

AU - Churesigaew, Sunchai

AU - Hemsrichart, Vichitra

PY - 1998/10/1

Y1 - 1998/10/1

N2 - The authors reported a twelve year and four-month old girl who had prolonged fever for 2 weeks. Physical examination revealed a painless enlarged thyroid gland with firm consistency. Hyperparathyroidism was suspected because of hypercalcemia, hypophosphatemia, high level of serum alkaline phosphatase, and decreased density of long bones. Thyroid scan showed a cold nodule of the left upper lobe which subsequently proved to be a medullary thyroid carcinoma by high serum thyrocalcitonin level and pathological examination. Her 24-hour urinary vanillyl mandelic acid was in the normal range, and abdominal ultrasonography demonstrated normal adrenal glands. Multiple endocrine neoplasia type IIa (MEN IIa) was diagnosed by medullary thyroid carcinoma and hyperparathyroidism. However, the fully developed syndrome is characterized by the combined occurrence of medullary thyroid carcinoma, primary hyperparathyroidism, and pheochromocytomas. This syndrome is a rare, complex, and potentially lethal disease so early recognition and family screening are very important.

AB - The authors reported a twelve year and four-month old girl who had prolonged fever for 2 weeks. Physical examination revealed a painless enlarged thyroid gland with firm consistency. Hyperparathyroidism was suspected because of hypercalcemia, hypophosphatemia, high level of serum alkaline phosphatase, and decreased density of long bones. Thyroid scan showed a cold nodule of the left upper lobe which subsequently proved to be a medullary thyroid carcinoma by high serum thyrocalcitonin level and pathological examination. Her 24-hour urinary vanillyl mandelic acid was in the normal range, and abdominal ultrasonography demonstrated normal adrenal glands. Multiple endocrine neoplasia type IIa (MEN IIa) was diagnosed by medullary thyroid carcinoma and hyperparathyroidism. However, the fully developed syndrome is characterized by the combined occurrence of medullary thyroid carcinoma, primary hyperparathyroidism, and pheochromocytomas. This syndrome is a rare, complex, and potentially lethal disease so early recognition and family screening are very important.

UR - http://www.scopus.com/inward/record.url?scp=0032176732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032176732&partnerID=8YFLogxK

M3 - Article

VL - 81

SP - 788

EP - 793

JO - Journal of the Medical Association of Thailand

JF - Journal of the Medical Association of Thailand

SN - 0125-2208

IS - 10

ER -