Multiple γc-dependent cytokines regulate T-cell development

Thomas R. Malek, Brian O. Porter, You Wen He

Research output: Contribution to journalComment/debate

58 Scopus citations

Abstract

Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalImmunology Today
Volume20
Issue number2
DOIs
StatePublished - Feb 1 1999

ASJC Scopus subject areas

  • Immunology

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