Multiple γc-dependent cytokines regulate T-cell development

Thomas R. Malek; Brian O. Porter; You Wen He

doi:10.1016/S0167-5699(98)01391-7

Multiple γc-dependent cytokines regulate T-cell development

Thomas R. Malek, Brian O. Porter, You Wen He

Microbiology & Immunology

Research output: Contribution to journal › Comment/debate › peer-review

58 Scopus citations

Abstract

Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

Original language	English (US)
Pages (from-to)	71-76
Number of pages	6
Journal	Immunology Today
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/S0167-5699(98)01391-7
State	Published - Feb 1 1999

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/S0167-5699(98)01391-7

Fingerprint Dive into the research topics of 'Multiple γc-dependent cytokines regulate T-cell development'. Together they form a unique fingerprint.

Cite this

@article{6a6140a6cbab4bc694ba61133c40b7f8,

title = "Multiple γc-dependent cytokines regulate T-cell development",

abstract = "Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.",

author = "Malek, {Thomas R.} and Porter, {Brian O.} and He, {You Wen}",

year = "1999",

month = feb,

day = "1",

doi = "10.1016/S0167-5699(98)01391-7",

language = "English (US)",

volume = "20",

pages = "71--76",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Multiple γc-dependent cytokines regulate T-cell development

AU - Malek, Thomas R.

AU - Porter, Brian O.

AU - He, You Wen

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

AB - Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

UR - http://www.scopus.com/inward/record.url?scp=0033082369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033082369&partnerID=8YFLogxK

U2 - 10.1016/S0167-5699(98)01391-7

DO - 10.1016/S0167-5699(98)01391-7

M3 - Comment/debate

C2 - 10098325

AN - SCOPUS:0033082369

VL - 20

SP - 71

EP - 76

JO - Trends in Immunology

JF - Trends in Immunology

SN - 1471-4906

IS - 2

ER -