Abstract
Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.
Original language | English (US) |
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Pages (from-to) | 71-76 |
Number of pages | 6 |
Journal | Immunology Today |
Volume | 20 |
Issue number | 2 |
DOIs |
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State | Published - Feb 1 1999 |
ASJC Scopus subject areas
- Immunology