Multiple γc-dependent cytokines regulate T-cell development

Thomas R. Malek; Brian O. Porter; You Wen He

doi:10.1016/S0167-5699(98)01391-7

Multiple γc-dependent cytokines regulate T-cell development

Thomas R. Malek, Brian O. Porter, You Wen He

Microbiology & Immunology

Research output: Contribution to journal › Comment/debate › peer-review

58 Scopus citations

Abstract

Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

Original language	English (US)
Pages (from-to)	71-76
Number of pages	6
Journal	Immunology Today
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/S0167-5699(98)01391-7
State	Published - Feb 1 1999

ASJC Scopus subject areas

Immunology

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title = "Multiple γc-dependent cytokines regulate T-cell development",

abstract = "Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.",

author = "Malek, {Thomas R.} and Porter, {Brian O.} and He, {You Wen}",

note = "Funding Information: We thank M. Flajnik, L. Boise and R. Adkins for critically reading this manuscript. Our research is supported by grants from the NCI and NIAID.",

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AU - Porter, Brian O.

AU - He, You Wen

N1 - Funding Information: We thank M. Flajnik, L. Boise and R. Adkins for critically reading this manuscript. Our research is supported by grants from the NCI and NIAID.

PY - 1999/2/1

Y1 - 1999/2/1

N2 - Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

AB - Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.

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JO - Trends in Immunology

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Multiple γc-dependent cytokines regulate T-cell development

Abstract

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