Abstract
Mutations in the common γ chain (γc) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. γc contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2 receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual γc-dependent cytokines in both conventional and intraepithelial T-cell development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-76 |
| Number of pages | 6 |
| Journal | Immunology Today |
| Volume | 20 |
| Issue number | 2 |
| DOIs |
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| State | Published - Feb 1 1999 |
ASJC Scopus subject areas
- Immunology
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Cite this
Malek, T. R., Porter, B. O., & He, Y. W. (1999). Multiple γc-dependent cytokines regulate T-cell development. Immunology Today, 20(2), 71-76. https://doi.org/10.1016/S0167-5699(98)01391-7