Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients

A. Zauner, E. Doppenberg, J. J. Woodward, C. Allen, S. Jebraili, H. F. Young, Ross Bullock

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Brain function and tissue integrity are highly dependent on continuous oxygen supply and clearance of CO2. Aerobic metabolism is the major energy source to normal brain, however, during hypoxia and ischemia, lactate accumulation may sometimes be seen, indicating anaerobic glycolysis after severe head injury. Current monitoring techniques often fail to detect such events which can affect substrate delivery to the injured brain. We have recently adapted a method for continuous monitoring of brain tissue pO2, pCO2, pH and temperature, using a single sensor. The multiparameter sensor is inserted into brain tissue, via a new three lumen bolt, together with a standard ventriculostomy catheter and a microdialysis probe. The system has been left in place as long as needed, but never more than 7 days. All readings were compared to clinical parameters, and outcome. Stable measurements could be obtained in the first group of 20 patients, after calibration and rigid fixation, using the new bolt. Severely head injured patients had brain oxygen levels of less than 25-30 mmHg for the first hours after injury. Thereafter two patterns could be seen. Patients with favorable outcome had a slow increase in brain oxygen, and brain CO2 decreased to normal values, as long as the cerebral perfusion pressure (CPP) was kept above 70 mmHg. However, in those patients with secondary ischemic events, and bad outcome, a further decline in brain oxygen to anaerobic levels (< 20 mmHg) was seen. For these patients, both decreased and increased brain CO2 levels could be seen. Brain CO2 levels of 90-150 mmHg were consistently seen after brain death. Brain pH was inversely related to brain CO2 for all patients. Brain glucose and lactate in patients with poor outcome were 639 μM I-1 ± 330, and 1642 μM I-1 ± 788, whereas patients with good outcome had brain glucose levels of 808 μM I-1 ± 321 and lactate levels of 1001 μM I-1 ± 417. Extended neuromonitoring using a combined sensor for brain oxygen, CO2, pH and temperature measurements, as well as a microdialysis probe for glucose and lactate analysis may optimize the management of comatose neurosurgical patients in the future, by allowing a fuller understanding of dynamic factors affecting brain metabolism.

Original languageEnglish
Pages (from-to)265-273
Number of pages9
JournalNeurological Research
Volume19
Issue number3
StatePublished - Jun 26 1997
Externally publishedYes

Fingerprint

Brain
Oxygen
Lactic Acid
Microdialysis
Glucose
Cerebrovascular Circulation
Ventriculostomy
Temperature
Brain Death
Glycolysis
Coma
Craniocerebral Trauma
Calibration
Reading
Reference Values
Ischemia
Catheters
Head
Wounds and Injuries

Keywords

  • Carbon dioxide clearance
  • Hypoxia
  • Ischemia
  • Multiparameter sensor
  • Oxygen supply

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Zauner, A., Doppenberg, E., Woodward, J. J., Allen, C., Jebraili, S., Young, H. F., & Bullock, R. (1997). Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. Neurological Research, 19(3), 265-273.

Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. / Zauner, A.; Doppenberg, E.; Woodward, J. J.; Allen, C.; Jebraili, S.; Young, H. F.; Bullock, Ross.

In: Neurological Research, Vol. 19, No. 3, 26.06.1997, p. 265-273.

Research output: Contribution to journalArticle

Zauner, A, Doppenberg, E, Woodward, JJ, Allen, C, Jebraili, S, Young, HF & Bullock, R 1997, 'Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients', Neurological Research, vol. 19, no. 3, pp. 265-273.
Zauner A, Doppenberg E, Woodward JJ, Allen C, Jebraili S, Young HF et al. Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. Neurological Research. 1997 Jun 26;19(3):265-273.
Zauner, A. ; Doppenberg, E. ; Woodward, J. J. ; Allen, C. ; Jebraili, S. ; Young, H. F. ; Bullock, Ross. / Multiparametric continuous monitoring of brain metabolism and substrate delivery in neurosurgical patients. In: Neurological Research. 1997 ; Vol. 19, No. 3. pp. 265-273.
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