Multimodality therapy for advanced and recurrent vulvar squamous cell carcinoma

A pilot project

L. F. Carson, L. B. Twiggs, L. L. Adcock, K. A. Prem, R. A. Potish

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

From 1985 to 1989 eight women with advanced or recurrent vulvar carcinoma were treated at the Women's Cancer Center of the University of Minnesota Hospital and Clinic. Each received a combination of 5-fluorouracil, mitomycin C and cisplatin during radiotherapy. Five of the eight women who underwent posttreatment radical vulvectomy had acceptable operative morbidity. Six patients experienced a complete clinical response. Of them, one had microscopic residual disease in the surgical specimen. One patient with recurrent vulvar carcinoma experienced progression of disease on therapy. One death was attributable to chemotherapy toxicity, and two patients died of intercurrent disease. The overall survival rate at 27 months was 33%. This multimodality approach to the treatment of advanced vulvar carcinoma should be considered when designing a therapeutic approach to treating extensive or resistant vulvar carcinoma.

Original languageEnglish
Pages (from-to)1029-1032
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume35
Issue number11
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

Squamous Cell Carcinoma
Carcinoma
Mitomycin
Therapeutics
Fluorouracil
Cisplatin
Disease Progression
Radiotherapy
Survival Rate
Morbidity
Drug Therapy
Neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Multimodality therapy for advanced and recurrent vulvar squamous cell carcinoma : A pilot project. / Carson, L. F.; Twiggs, L. B.; Adcock, L. L.; Prem, K. A.; Potish, R. A.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 35, No. 11, 01.12.1990, p. 1029-1032.

Research output: Contribution to journalArticle

Carson, L. F. ; Twiggs, L. B. ; Adcock, L. L. ; Prem, K. A. ; Potish, R. A. / Multimodality therapy for advanced and recurrent vulvar squamous cell carcinoma : A pilot project. In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist. 1990 ; Vol. 35, No. 11. pp. 1029-1032.
@article{4822fecc9bab43df840235268b5249af,
title = "Multimodality therapy for advanced and recurrent vulvar squamous cell carcinoma: A pilot project",
abstract = "From 1985 to 1989 eight women with advanced or recurrent vulvar carcinoma were treated at the Women's Cancer Center of the University of Minnesota Hospital and Clinic. Each received a combination of 5-fluorouracil, mitomycin C and cisplatin during radiotherapy. Five of the eight women who underwent posttreatment radical vulvectomy had acceptable operative morbidity. Six patients experienced a complete clinical response. Of them, one had microscopic residual disease in the surgical specimen. One patient with recurrent vulvar carcinoma experienced progression of disease on therapy. One death was attributable to chemotherapy toxicity, and two patients died of intercurrent disease. The overall survival rate at 27 months was 33{\%}. This multimodality approach to the treatment of advanced vulvar carcinoma should be considered when designing a therapeutic approach to treating extensive or resistant vulvar carcinoma.",
author = "Carson, {L. F.} and Twiggs, {L. B.} and Adcock, {L. L.} and Prem, {K. A.} and Potish, {R. A.}",
year = "1990",
month = "12",
day = "1",
language = "English",
volume = "35",
pages = "1029--1032",
journal = "The Journal of reproductive medicine",
issn = "0024-7758",
publisher = "Donna Kessel",
number = "11",

}

TY - JOUR

T1 - Multimodality therapy for advanced and recurrent vulvar squamous cell carcinoma

T2 - A pilot project

AU - Carson, L. F.

AU - Twiggs, L. B.

AU - Adcock, L. L.

AU - Prem, K. A.

AU - Potish, R. A.

PY - 1990/12/1

Y1 - 1990/12/1

N2 - From 1985 to 1989 eight women with advanced or recurrent vulvar carcinoma were treated at the Women's Cancer Center of the University of Minnesota Hospital and Clinic. Each received a combination of 5-fluorouracil, mitomycin C and cisplatin during radiotherapy. Five of the eight women who underwent posttreatment radical vulvectomy had acceptable operative morbidity. Six patients experienced a complete clinical response. Of them, one had microscopic residual disease in the surgical specimen. One patient with recurrent vulvar carcinoma experienced progression of disease on therapy. One death was attributable to chemotherapy toxicity, and two patients died of intercurrent disease. The overall survival rate at 27 months was 33%. This multimodality approach to the treatment of advanced vulvar carcinoma should be considered when designing a therapeutic approach to treating extensive or resistant vulvar carcinoma.

AB - From 1985 to 1989 eight women with advanced or recurrent vulvar carcinoma were treated at the Women's Cancer Center of the University of Minnesota Hospital and Clinic. Each received a combination of 5-fluorouracil, mitomycin C and cisplatin during radiotherapy. Five of the eight women who underwent posttreatment radical vulvectomy had acceptable operative morbidity. Six patients experienced a complete clinical response. Of them, one had microscopic residual disease in the surgical specimen. One patient with recurrent vulvar carcinoma experienced progression of disease on therapy. One death was attributable to chemotherapy toxicity, and two patients died of intercurrent disease. The overall survival rate at 27 months was 33%. This multimodality approach to the treatment of advanced vulvar carcinoma should be considered when designing a therapeutic approach to treating extensive or resistant vulvar carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=0025648363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025648363&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 1029

EP - 1032

JO - The Journal of reproductive medicine

JF - The Journal of reproductive medicine

SN - 0024-7758

IS - 11

ER -