Multimodal treatment of Coats-like exudative vitreoretinopathy in Goldmann-Favre syndrome

Fabiola Ramos Nieves, Victor M. Villegas, Nimesh A. Patel, Audina M. Berrocal, Timothy G. Murray

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To report a Coats-like exudative vitreoretinopathy in Goldmann-Favre syndrome. Observations: A 64 year-old woman with prior diagnosis of retinal dystrophy presented with decreased vision in the right eye (OD). Ophthalmologic examination was remarkable for bilateral arteriolar attenuation, mid-peripheral bony-spicules, and waxy disc pallor. Coats-like exudative vitreoretinopathy and cystoid macular edema were present OD. Genetic testing showed a homozygous pathogenic mutation in gene NR2E3, variant c.932G>A (p.Arg311Gln), consistent with Goldmann-Favre syndrome. Targeted laser ablation and combination intravitreal therapy were effective in decreasing macular edema. Conclusions and Importance: A Coats-like exudative vitreoretinopathy may occur in the setting of Goldmann-Favre syndrome. Targeted laser ablation in combination with intravitreal therapy can be efficacious in select patients.

Original languageEnglish (US)
Article number101362
JournalAmerican Journal of Ophthalmology Case Reports
Volume25
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • Bevacizumab
  • Coats disease
  • Goldmann-Favre
  • Intravitreal therapy
  • Triamcinolone acetonide

ASJC Scopus subject areas

  • Ophthalmology

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