Abstract
Present wound care is primarily visual, entailing repeated clinical trips. A biosensing system offering direct longitudinal measures of healing can assist to bridge the time between occurrence of wounds and their management. Purine metabolites, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased apoptosis, concentrations of these analytes reportedly increase. In this study, their biochemical pathways in purine metabolism are explored to provide a method to monitor healing on a multimodal sensing platform. This work employs enzymes xanthine oxidase and uricase, for detection of uric acid and xanthine respectively. pH of wounds change with healing, from alkaline to acidic, shifting the potential of detection. Effects of pH have been investigated on the same platform enabling real-time calibration, attempting to provide improved assessment of tissue recovery. Nanomaterials of carbon (C) and gold (Au) have been utilized here, to improve the sensitivity of detection.
| Original language | English (US) |
|---|---|
| Title of host publication | ECS Transactions |
| Editors | A. Khosla, M. Kaltenbrunner, F. D. Dos Santos, K. Fukushima, M. Yanagida, H. Furukawa, K. Ito, T.-Y. Chu, T. Saito, G. Milano, L. Nagahara, P. Sekhar, A. Kakugo, H. Matsui, T. Yoshida, M. White, Y. Masubuchi, S. Bhansali, S. Tokito, A. Nakai, T. Shiba, H. Ito, A. Masuhara |
| Publisher | Electrochemical Society Inc. |
| Pages | 419-426 |
| Number of pages | 8 |
| Edition | 1 |
| ISBN (Electronic) | 9781607685395 |
| DOIs | |
| State | Published - Jan 1 2019 |
| Event | 1st International Conference on 4D Materials and Systems, 4DMS 2018 - Yonezawa, Japan Duration: Aug 26 2018 → Aug 30 2018 |
Publication series
| Name | ECS Transactions |
|---|---|
| Number | 1 |
| Volume | 88 |
| ISSN (Print) | 1938-6737 |
| ISSN (Electronic) | 1938-5862 |
Conference
| Conference | 1st International Conference on 4D Materials and Systems, 4DMS 2018 |
|---|---|
| Country | Japan |
| City | Yonezawa |
| Period | 8/26/18 → 8/30/18 |
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ASJC Scopus subject areas
- Engineering(all)
Cite this
Multimodal enzymatic sensing for continuous wound monitoring. / RoyChoudhury, S.; Bhushan, P.; Umasankar, Y.; Hirt, P. A.; Lev-Tov, Hadar; Kirsner, Robert; Bhansali, S.
ECS Transactions. ed. / A. Khosla; M. Kaltenbrunner; F. D. Dos Santos; K. Fukushima; M. Yanagida; H. Furukawa; K. Ito; T.-Y. Chu; T. Saito; G. Milano; L. Nagahara; P. Sekhar; A. Kakugo; H. Matsui; T. Yoshida; M. White; Y. Masubuchi; S. Bhansali; S. Tokito; A. Nakai; T. Shiba; H. Ito; A. Masuhara. 1. ed. Electrochemical Society Inc., 2019. p. 419-426 (ECS Transactions; Vol. 88, No. 1).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Multimodal enzymatic sensing for continuous wound monitoring
AU - RoyChoudhury, S.
AU - Bhushan, P.
AU - Umasankar, Y.
AU - Hirt, P. A.
AU - Lev-Tov, Hadar
AU - Kirsner, Robert
AU - Bhansali, S.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Present wound care is primarily visual, entailing repeated clinical trips. A biosensing system offering direct longitudinal measures of healing can assist to bridge the time between occurrence of wounds and their management. Purine metabolites, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased apoptosis, concentrations of these analytes reportedly increase. In this study, their biochemical pathways in purine metabolism are explored to provide a method to monitor healing on a multimodal sensing platform. This work employs enzymes xanthine oxidase and uricase, for detection of uric acid and xanthine respectively. pH of wounds change with healing, from alkaline to acidic, shifting the potential of detection. Effects of pH have been investigated on the same platform enabling real-time calibration, attempting to provide improved assessment of tissue recovery. Nanomaterials of carbon (C) and gold (Au) have been utilized here, to improve the sensitivity of detection.
AB - Present wound care is primarily visual, entailing repeated clinical trips. A biosensing system offering direct longitudinal measures of healing can assist to bridge the time between occurrence of wounds and their management. Purine metabolites, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased apoptosis, concentrations of these analytes reportedly increase. In this study, their biochemical pathways in purine metabolism are explored to provide a method to monitor healing on a multimodal sensing platform. This work employs enzymes xanthine oxidase and uricase, for detection of uric acid and xanthine respectively. pH of wounds change with healing, from alkaline to acidic, shifting the potential of detection. Effects of pH have been investigated on the same platform enabling real-time calibration, attempting to provide improved assessment of tissue recovery. Nanomaterials of carbon (C) and gold (Au) have been utilized here, to improve the sensitivity of detection.
UR - http://www.scopus.com/inward/record.url?scp=85064967056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064967056&partnerID=8YFLogxK
U2 - 10.1149/08801.0419ecst
DO - 10.1149/08801.0419ecst
M3 - Conference contribution
T3 - ECS Transactions
SP - 419
EP - 426
BT - ECS Transactions
A2 - Khosla, A.
A2 - Kaltenbrunner, M.
A2 - Dos Santos, F. D.
A2 - Fukushima, K.
A2 - Yanagida, M.
A2 - Furukawa, H.
A2 - Ito, K.
A2 - Chu, T.-Y.
A2 - Saito, T.
A2 - Milano, G.
A2 - Nagahara, L.
A2 - Sekhar, P.
A2 - Kakugo, A.
A2 - Matsui, H.
A2 - Yoshida, T.
A2 - White, M.
A2 - Masubuchi, Y.
A2 - Bhansali, S.
A2 - Tokito, S.
A2 - Nakai, A.
A2 - Shiba, T.
A2 - Ito, H.
A2 - Masuhara, A.
PB - Electrochemical Society Inc.
ER -