Multimodal enzymatic sensing for continuous wound monitoring

S. RoyChoudhury, P. Bhushan, Y. Umasankar, P. A. Hirt, Hadar Lev-Tov, Robert Kirsner, S. Bhansali

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Present wound care is primarily visual, entailing repeated clinical trips. A biosensing system offering direct longitudinal measures of healing can assist to bridge the time between occurrence of wounds and their management. Purine metabolites, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased apoptosis, concentrations of these analytes reportedly increase. In this study, their biochemical pathways in purine metabolism are explored to provide a method to monitor healing on a multimodal sensing platform. This work employs enzymes xanthine oxidase and uricase, for detection of uric acid and xanthine respectively. pH of wounds change with healing, from alkaline to acidic, shifting the potential of detection. Effects of pH have been investigated on the same platform enabling real-time calibration, attempting to provide improved assessment of tissue recovery. Nanomaterials of carbon (C) and gold (Au) have been utilized here, to improve the sensitivity of detection.

Original languageEnglish (US)
Title of host publicationECS Transactions
EditorsA. Khosla, M. Kaltenbrunner, F. D. Dos Santos, K. Fukushima, M. Yanagida, H. Furukawa, K. Ito, T.-Y. Chu, T. Saito, G. Milano, L. Nagahara, P. Sekhar, A. Kakugo, H. Matsui, T. Yoshida, M. White, Y. Masubuchi, S. Bhansali, S. Tokito, A. Nakai, T. Shiba, H. Ito, A. Masuhara
PublisherElectrochemical Society Inc.
Pages419-426
Number of pages8
Edition1
ISBN (Electronic)9781607685395
DOIs
StatePublished - Jan 1 2019
Event1st International Conference on 4D Materials and Systems, 4DMS 2018 - Yonezawa, Japan
Duration: Aug 26 2018Aug 30 2018

Publication series

NameECS Transactions
Number1
Volume88
ISSN (Print)1938-6737
ISSN (Electronic)1938-5862

Conference

Conference1st International Conference on 4D Materials and Systems, 4DMS 2018
CountryJapan
CityYonezawa
Period8/26/188/30/18

ASJC Scopus subject areas

  • Engineering(all)

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    RoyChoudhury, S., Bhushan, P., Umasankar, Y., Hirt, P. A., Lev-Tov, H., Kirsner, R., & Bhansali, S. (2019). Multimodal enzymatic sensing for continuous wound monitoring. In A. Khosla, M. Kaltenbrunner, F. D. Dos Santos, K. Fukushima, M. Yanagida, H. Furukawa, K. Ito, T-Y. Chu, T. Saito, G. Milano, L. Nagahara, P. Sekhar, A. Kakugo, H. Matsui, T. Yoshida, M. White, Y. Masubuchi, S. Bhansali, S. Tokito, A. Nakai, T. Shiba, H. Ito, ... A. Masuhara (Eds.), ECS Transactions (1 ed., pp. 419-426). (ECS Transactions; Vol. 88, No. 1). Electrochemical Society Inc.. https://doi.org/10.1149/08801.0419ecst