@inproceedings{e0864f415bfa48a6a97f6ce45d9796fe,
title = "Multimodal enzymatic sensing for continuous wound monitoring",
abstract = "Present wound care is primarily visual, entailing repeated clinical trips. A biosensing system offering direct longitudinal measures of healing can assist to bridge the time between occurrence of wounds and their management. Purine metabolites, xanthine and uric acid, are known to have high correlation with wound chronicity and healing. With increased apoptosis, concentrations of these analytes reportedly increase. In this study, their biochemical pathways in purine metabolism are explored to provide a method to monitor healing on a multimodal sensing platform. This work employs enzymes xanthine oxidase and uricase, for detection of uric acid and xanthine respectively. pH of wounds change with healing, from alkaline to acidic, shifting the potential of detection. Effects of pH have been investigated on the same platform enabling real-time calibration, attempting to provide improved assessment of tissue recovery. Nanomaterials of carbon (C) and gold (Au) have been utilized here, to improve the sensitivity of detection.",
author = "S. RoyChoudhury and P. Bhushan and Y. Umasankar and Hirt, {P. A.} and Lev-Tov, {H. A.} and Kirsner, {R. S.} and S. Bhansali",
note = "Funding Information: This work is being supported by the NSF Nano-systems Engineering Research Centre for Advanced Self-Powered Systems of Integrated Biosensors and Technologies (ASSIST) under Award Number (EEC-1160483).; 1st International Conference on 4D Materials and Systems, 4DMS 2018 ; Conference date: 26-08-2018 Through 30-08-2018",
year = "2019",
doi = "10.1149/08801.0419ecst",
language = "English (US)",
series = "ECS Transactions",
publisher = "Electrochemical Society Inc.",
number = "1",
pages = "419--426",
editor = "K. Fukushima and K. Ito and S. Bhansali and A. Nakai and A. Khosla and L. Nagahara and P. Sekhar and S. Tokito and T. Saito and G. Milano and H. Matsui and T. Shiba and {Dos Santos}, {F. D.} and H. Furukawa and Y. Masubuchi and M. Yanagida and H. Ito and M. Kaltenbrunner and A. Kakugo and M. White and T.-Y. Chu and T. Yoshida and A. Masuhara",
booktitle = "ECS Transactions",
edition = "1",
}