Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer

Argyro Fassoulaki, Argyro Triga, Aikaterini Melemeni, Konstantinos D. Sarantopoulos

Research output: Contribution to journalArticle

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Abstract

We evaluated the effect of multimodal analgesia on acute and chronic pain after breast surgery for cancer. Fifty patients scheduled for breast cancer surgery were blindly randomized to receive gabapentin, eutectic mixture of local anesthetics cream, and ropivacaine in the wound or three placebos. Pain (visual analog scale) and analgesics were recorded in the postanesthesia care unit (PACU) 3,6, and 9 h and 8 days after surgery. Three and 6 mo later, patients were assessed for chronic pain. The treatment group consumed less paracetamol in the PACU (469 versus 991 mg; P < 0.002) and less Lonalgal® (1.0 versus 4.4 tablets; P = 0.003) than the controls, exhibited lower visual analog scale scores at rest in the PACU (P = 0.001) and on postoperative Days 1,3, and 5 (P = 0.040, P = 0.015, and P = 0.045, respectively), and after movement in the PACU (P = 0.001) and on postoperative Days 2,4, and 8 (P = 0.028, P = 0.007, and P = 0.032, respectively). Three and 6 mo after surgery, 18 of 22 (82%) and 12 of 21 (57%) of the controls reported chronic pain versus 10 of 22 (45%) and 6 of 20 (30%) in the treatment group (P = 0.028 and P = 0.424, respectively); 5 of 22 and 4 of 21 of the controls required analgesics versus 0 of 22 and 0 of 20 of those treated (P = 0.048 and P = 0.107, respectively). Multimodal analgesia reduced acute and chronic pain after breast surgery for cancer.

Original languageEnglish
Pages (from-to)1427-1432
Number of pages6
JournalAnesthesia and Analgesia
Volume101
Issue number5
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

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Acute Pain
Local Anesthetics
Chronic Pain
Analgesia
Breast Neoplasms
Analgesics
Pain Measurement
Acetaminophen
Visual Analog Scale
Ambulatory Surgical Procedures
Tablets
Placebos
gabapentin
Wounds and Injuries
Therapeutics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Multimodal analgesia with gabapentin and local anesthetics prevents acute and chronic pain after breast surgery for cancer. / Fassoulaki, Argyro; Triga, Argyro; Melemeni, Aikaterini; Sarantopoulos, Konstantinos D.

In: Anesthesia and Analgesia, Vol. 101, No. 5, 01.11.2005, p. 1427-1432.

Research output: Contribution to journalArticle

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