Multifocal G1-G2 gastric neuroendocrine tumors: Differentiating between Type I, II and III, a clinicopathologic review

Khaled Algashaamy, Monica Garcia-Buitrago

Research output: Contribution to journalShort survey

Abstract

Gastric neuroendocrine tumors (gNETs) are a rare entity that is increasing in incidence. Different pathophysiological processes can lead to the development of these tumors, appropriate histological analysis is necessary to differentiate between grade 1 (G1) and grade 2 (G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant metastases. To provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors, with particular emphasis on G1 and G2 tumors and differentiating between types I, II and II and risk stratification based upon immunohistochemical profile. This review is based on peer-reviewed literature and the authors' experience. gNETs are a heterogenous group of tumors that is rising in incidence. These lesions while arise from the same cell type, they have different etiologies. Identifying the type of gNETs is a collective effort of clinical and pathologic correlation. The correct grading and staging of these lesions are of paramount significance, due its impact on patient management and prognosis.

Original languageEnglish (US)
Pages (from-to)2413-2419
Number of pages7
JournalWorld Journal of Clinical Cases
Volume7
Issue number17
DOIs
StatePublished - Sep 1 2019

Keywords

  • Diagnosis
  • Enterochromaffin like cells
  • Gastric neuroendocrine tumors
  • Histopathological features
  • Immunohistochemistry
  • Treatment

ASJC Scopus subject areas

  • Medicine(all)

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