Abstract
Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms which account for less than 1% of all gastrointestinal malignancies. Of all the extra-abdominal metastases of GIST, superficial soft tissue metastases are the rarest. Previous reports have found success with sunitinib in imatinib-resistant GIST, but we report a certain wild-type KIT mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor (TKI) treatments. This case illustrates that knowing the specific type of KIT mutations may uncover resistance of certain GIST's to TKIs, necessitating more targeted and alternative therapy.
| Original language | English (US) |
|---|---|
| Journal | Journal of Cutaneous Pathology |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- cutaneous
- cutaneous metastasis
- gastric cancer
- gastrointestinal stromal tumors
- neoplasm metastasis
- skin
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Dermatology
Cite this
Multidrug resistant gastrointestinal stromal tumor with multiple metastases to the skin and subcutaneous soft tissue : A case report and review of literature. / Aickara, Divya J.; McBride, Jeffrey; Morrison, Brian; Romanelli, Paolo.
In: Journal of Cutaneous Pathology, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multidrug resistant gastrointestinal stromal tumor with multiple metastases to the skin and subcutaneous soft tissue
T2 - A case report and review of literature
AU - Aickara, Divya J.
AU - McBride, Jeffrey
AU - Morrison, Brian
AU - Romanelli, Paolo
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms which account for less than 1% of all gastrointestinal malignancies. Of all the extra-abdominal metastases of GIST, superficial soft tissue metastases are the rarest. Previous reports have found success with sunitinib in imatinib-resistant GIST, but we report a certain wild-type KIT mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor (TKI) treatments. This case illustrates that knowing the specific type of KIT mutations may uncover resistance of certain GIST's to TKIs, necessitating more targeted and alternative therapy.
AB - Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms which account for less than 1% of all gastrointestinal malignancies. Of all the extra-abdominal metastases of GIST, superficial soft tissue metastases are the rarest. Previous reports have found success with sunitinib in imatinib-resistant GIST, but we report a certain wild-type KIT mutation GIST with cutaneous and subcutaneous metastasis that was unresponsive to multiple tyrosine kinase inhibitor (TKI) treatments. This case illustrates that knowing the specific type of KIT mutations may uncover resistance of certain GIST's to TKIs, necessitating more targeted and alternative therapy.
KW - cutaneous
KW - cutaneous metastasis
KW - gastric cancer
KW - gastrointestinal stromal tumors
KW - neoplasm metastasis
KW - skin
UR - http://www.scopus.com/inward/record.url?scp=85075422589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85075422589&partnerID=8YFLogxK
U2 - 10.1111/cup.13611
DO - 10.1111/cup.13611
M3 - Article
AN - SCOPUS:85075422589
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
SN - 0303-6987
ER -