Multidimensional system biology: Genetic markers and proteomic biomarkers of adverse pregnancy outcome in preterm birth

Catalin S. Buhimschi, Victor A. Rosenberg, Antonette T. Dulay, Stephen Thung, Anna K. Sfakianaki, Mert Ozan Bahtiyar, Irina A. Buhimschi

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Premature birth before 37 weeks of gestation is a significant public health problem. Each year, 4.5 million premature infants are born worldwide. Despite extensive research and a variety of interventions, the rate of preterm birth has steadily increased over the past 20 years and reached a high of 12.8% in 2006. The etiology of most preterm births remains elusive and is likely multifactorial, with many pathophysiological pathways involved, such as excessive stretching, oxidative stress, decidual hemorrhage, and infection. Genomics and proteomics have emerged to provide a better comprehension of the pathophysiological conditions leading to preterm birth, thereby providing a perspective for improving neonatal outcome.

Original languageEnglish (US)
Pages (from-to)175-187
Number of pages13
JournalAmerican Journal of Perinatology
Volume25
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

Keywords

  • Genomics
  • Preterm birth
  • Proteomics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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