Abstract
The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1-3) OR presence of a central venous catheter (days 1-3) AND at least TWO of the following-total parenteral nutrition (days 1-3), any dialysis (days 1-3), any major surgery (days -7-0), pancreatitis (days -7-0), any use of steroids (days -7-3), or use of other immunosuppressive agents (days -7-0). The rate of invasive candidiasis among patients meeting the rule was 9.9%, capturing 34% of cases in the units, with the following performance: relative risk 4.36, sensitivity 0.34, specificity 0.90, positive predictive value 0.01, and negative predictive value 0.97. The rule may identify patients at high risk of invasive candidiasis.
| Original language | English |
|---|---|
| Pages (from-to) | 271-276 |
| Number of pages | 6 |
| Journal | European Journal of Clinical Microbiology and Infectious Diseases |
| Volume | 26 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2007 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Immunology
Cite this
Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting. / Ostrosky-Zeichner, L.; Sable, C.; Sobel, J.; Alexander, B. D.; Donowitz, G.; Kan, V.; Kauffman, C. A.; Kett, Daniel H; Larsen, R. A.; Morrison, V.; Nucci, M.; Pappas, P. G.; Bradley, M. E.; Major, S.; Zimmer, L.; Wallace, D.; Dismukes, W. E.; Rex, J. H.
In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 26, No. 4, 01.04.2007, p. 271-276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting
AU - Ostrosky-Zeichner, L.
AU - Sable, C.
AU - Sobel, J.
AU - Alexander, B. D.
AU - Donowitz, G.
AU - Kan, V.
AU - Kauffman, C. A.
AU - Kett, Daniel H
AU - Larsen, R. A.
AU - Morrison, V.
AU - Nucci, M.
AU - Pappas, P. G.
AU - Bradley, M. E.
AU - Major, S.
AU - Zimmer, L.
AU - Wallace, D.
AU - Dismukes, W. E.
AU - Rex, J. H.
PY - 2007/4/1
Y1 - 2007/4/1
N2 - The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1-3) OR presence of a central venous catheter (days 1-3) AND at least TWO of the following-total parenteral nutrition (days 1-3), any dialysis (days 1-3), any major surgery (days -7-0), pancreatitis (days -7-0), any use of steroids (days -7-3), or use of other immunosuppressive agents (days -7-0). The rate of invasive candidiasis among patients meeting the rule was 9.9%, capturing 34% of cases in the units, with the following performance: relative risk 4.36, sensitivity 0.34, specificity 0.90, positive predictive value 0.01, and negative predictive value 0.97. The rule may identify patients at high risk of invasive candidiasis.
AB - The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1-3) OR presence of a central venous catheter (days 1-3) AND at least TWO of the following-total parenteral nutrition (days 1-3), any dialysis (days 1-3), any major surgery (days -7-0), pancreatitis (days -7-0), any use of steroids (days -7-3), or use of other immunosuppressive agents (days -7-0). The rate of invasive candidiasis among patients meeting the rule was 9.9%, capturing 34% of cases in the units, with the following performance: relative risk 4.36, sensitivity 0.34, specificity 0.90, positive predictive value 0.01, and negative predictive value 0.97. The rule may identify patients at high risk of invasive candidiasis.
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UR - http://www.scopus.com/inward/citedby.url?scp=34147136535&partnerID=8YFLogxK
U2 - 10.1007/s10096-007-0270-z
DO - 10.1007/s10096-007-0270-z
M3 - Article
C2 - 17333081
AN - SCOPUS:34147136535
VL - 26
SP - 271
EP - 276
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
SN - 0934-9723
IS - 4
ER -