Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection

P. Tryphonopoulos, D. Weppler, Seigo Nishida, T. Kato, D. Levi, Gennaro Selvaggi, J. Moon, J. R. Madariaga, J. DelaGarza, A. Tzakis, Phillip Ruiz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33% of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.

Original languageEnglish
Pages (from-to)1685-1686
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 1 2006

Fingerprint

Fibrosis
Allografts
Transplants
Biopsy
Kaplan-Meier Estimate
Graft Survival

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection. / Tryphonopoulos, P.; Weppler, D.; Nishida, Seigo; Kato, T.; Levi, D.; Selvaggi, Gennaro; Moon, J.; Madariaga, J. R.; DelaGarza, J.; Tzakis, A.; Ruiz, Phillip.

In: Transplantation Proceedings, Vol. 38, No. 6, 01.07.2006, p. 1685-1686.

Research output: Contribution to journalArticle

Tryphonopoulos, P, Weppler, D, Nishida, S, Kato, T, Levi, D, Selvaggi, G, Moon, J, Madariaga, JR, DelaGarza, J, Tzakis, A & Ruiz, P 2006, 'Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection', Transplantation Proceedings, vol. 38, no. 6, pp. 1685-1686. https://doi.org/10.1016/j.transproceed.2006.05.019
Tryphonopoulos, P. ; Weppler, D. ; Nishida, Seigo ; Kato, T. ; Levi, D. ; Selvaggi, Gennaro ; Moon, J. ; Madariaga, J. R. ; DelaGarza, J. ; Tzakis, A. ; Ruiz, Phillip. / Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 6. pp. 1685-1686.
@article{9b0aca3357a5463fb16681dc9f978597,
title = "Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection",
abstract = "Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33{\%} of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.",
author = "P. Tryphonopoulos and D. Weppler and Seigo Nishida and T. Kato and D. Levi and Gennaro Selvaggi and J. Moon and Madariaga, {J. R.} and J. DelaGarza and A. Tzakis and Phillip Ruiz",
year = "2006",
month = "7",
day = "1",
doi = "10.1016/j.transproceed.2006.05.019",
language = "English",
volume = "38",
pages = "1685--1686",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection

AU - Tryphonopoulos, P.

AU - Weppler, D.

AU - Nishida, Seigo

AU - Kato, T.

AU - Levi, D.

AU - Selvaggi, Gennaro

AU - Moon, J.

AU - Madariaga, J. R.

AU - DelaGarza, J.

AU - Tzakis, A.

AU - Ruiz, Phillip

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33% of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.

AB - Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33% of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.

UR - http://www.scopus.com/inward/record.url?scp=33746923432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746923432&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2006.05.019

DO - 10.1016/j.transproceed.2006.05.019

M3 - Article

C2 - 16908247

AN - SCOPUS:33746923432

VL - 38

SP - 1685

EP - 1686

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 6

ER -