Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection

Panagiotis Tryphonopoulos, D. Weppler, S. Nishida, T. Kato, D. Levi, G. Selvaggi, J. Moon, J. R. Madariaga, J. DelaGarza, A. Tzakis, P. Ruiz

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Endoscopic biopsies of intestinal allografts are limited to the superficial layers of the bowel. We investigated whether the presence of mucosal fibrosis in graft biopsies was indicative of chronic allograft rejection. We examined graft biopsies of 182 intestinal transplant recipients for the presence of mucosal fibrosis. Kaplan-Meier analysis showed that within 5 years posttransplantation 33% of intestinal transplant patients had graft biopsies positive for mucosal fibrosis. Although the presence of mucosal fibrosis did not affect patient or graft survival, patients with this lesion were at higher risk of developing chronic allograft enteropathy.

Original languageEnglish (US)
Pages (from-to)1685-1686
Number of pages2
JournalTransplantation proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Tryphonopoulos, P., Weppler, D., Nishida, S., Kato, T., Levi, D., Selvaggi, G., Moon, J., Madariaga, J. R., DelaGarza, J., Tzakis, A., & Ruiz, P. (2006). Mucosal Fibrosis in Intestinal Transplant Biopsies Correlates Positively With the Development of Chronic Rejection. Transplantation proceedings, 38(6), 1685-1686. https://doi.org/10.1016/j.transproceed.2006.05.019