Cancer mucoépidermoïde des glandes salivaires: signification pronostique des marqueurs tumoraux

Translated title of the contribution: Mucoepidermoid carcinoma of salivary glands: the prognostic value of tumoral markers

J. Hoyek-Gebeily, E. Nehmé, G. Aftimos, C. Sader-Ghorra, Zoukaa B Sargi, A. Haddad

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Mucoepidermoid carcinoma is one of the most frequent malignant lesions of salivary glands. The treatment is based on clinical, paraclinical and histological data. Several studies on the prognostic value of molecular markers for these cancers were made with contradictory results. The aim of this retrospective study was to analyze the prognostic value of molecular markers of salivary gland mucoepidermoid carcinoma. Material and methods: Sixteen patients were treated for mucoepidermoid carcinoma of principal and/or accessory salivary glands between 1994 and 2003. An immunohistochemical study of archive specimen was performed. Nine markers were specifically studied: 4 proteins/oncoproteins (p53, bcl2, c-erb-B2 and cd117), 2 markers of proliferation (PCNA and Ki67), 1 growing factor receptor (EGFR), 1 epithelial adhesion molecule (E-cadherin), and 1 angiogenic cytokine (PDGF). Results: Nine men and 7 women were included, with a mean age of 43.7 years (14-80). The mean diameter of tumors was 3.1 mm (1-14), and the parotid gland was the most frequent location. The mean global survival rate was 57.3 months with a median of 55 months. The 2 to 5 years survival expectation rate were 82.5% and 46.4% respectively. The mean survival rate for women was superior to that of men (P = 0.043). The expression of p53 and the high expression rate of EFGR were bad prognostic factors (respectively P = 0.049 and P = 0.012). The expression of PCNA was linked to the location (mainly the salivary gland) and to the diameter of the tumor (respectively P = 0.037 and P=0.029). The degree of EFGR positivity and the histological grade were linked (P = 0.027). Discussion: The strong expression of EGFR was statistically linked to the histological tumor grade. The degree of PCNA positivity seemed to be associated to the preferential location in the main salivary glands and to the diameter of the tumor. The strong expression of p53 and EGFR were bad prognostic factors. These retrospective results need to be confirmed by prospective randomized and larger studies. EGFR and p53 were significant negative prognostic factors. EGFR was highly correlated to the histological grade, making it an interesting target for further investigation.

Original languageFrench
Pages (from-to)482-488
Number of pages7
JournalRevue de Stomatologie et de Chirurgie Maxillo-Faciale
Volume108
Issue number6
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

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Mucoepidermoid Carcinoma
Salivary Glands
Proliferating Cell Nuclear Antigen
Survival Rate
Cadherins
Neoplasms
Tumor Suppressor Protein p53
Parotid Gland
Retrospective Studies
Cytokines
Proteins

Keywords

  • biological
  • EGFR
  • Mucoepidermoid carcinoma
  • PCNA
  • Tumor markers
  • Tumor suppressor Protein p53

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Oral Surgery

Cite this

Cancer mucoépidermoïde des glandes salivaires : signification pronostique des marqueurs tumoraux. / Hoyek-Gebeily, J.; Nehmé, E.; Aftimos, G.; Sader-Ghorra, C.; Sargi, Zoukaa B; Haddad, A.

In: Revue de Stomatologie et de Chirurgie Maxillo-Faciale, Vol. 108, No. 6, 01.12.2007, p. 482-488.

Research output: Contribution to journalArticle

Hoyek-Gebeily, J. ; Nehmé, E. ; Aftimos, G. ; Sader-Ghorra, C. ; Sargi, Zoukaa B ; Haddad, A. / Cancer mucoépidermoïde des glandes salivaires : signification pronostique des marqueurs tumoraux. In: Revue de Stomatologie et de Chirurgie Maxillo-Faciale. 2007 ; Vol. 108, No. 6. pp. 482-488.
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abstract = "Introduction: Mucoepidermoid carcinoma is one of the most frequent malignant lesions of salivary glands. The treatment is based on clinical, paraclinical and histological data. Several studies on the prognostic value of molecular markers for these cancers were made with contradictory results. The aim of this retrospective study was to analyze the prognostic value of molecular markers of salivary gland mucoepidermoid carcinoma. Material and methods: Sixteen patients were treated for mucoepidermoid carcinoma of principal and/or accessory salivary glands between 1994 and 2003. An immunohistochemical study of archive specimen was performed. Nine markers were specifically studied: 4 proteins/oncoproteins (p53, bcl2, c-erb-B2 and cd117), 2 markers of proliferation (PCNA and Ki67), 1 growing factor receptor (EGFR), 1 epithelial adhesion molecule (E-cadherin), and 1 angiogenic cytokine (PDGF). Results: Nine men and 7 women were included, with a mean age of 43.7 years (14-80). The mean diameter of tumors was 3.1 mm (1-14), and the parotid gland was the most frequent location. The mean global survival rate was 57.3 months with a median of 55 months. The 2 to 5 years survival expectation rate were 82.5{\%} and 46.4{\%} respectively. The mean survival rate for women was superior to that of men (P = 0.043). The expression of p53 and the high expression rate of EFGR were bad prognostic factors (respectively P = 0.049 and P = 0.012). The expression of PCNA was linked to the location (mainly the salivary gland) and to the diameter of the tumor (respectively P = 0.037 and P=0.029). The degree of EFGR positivity and the histological grade were linked (P = 0.027). Discussion: The strong expression of EGFR was statistically linked to the histological tumor grade. The degree of PCNA positivity seemed to be associated to the preferential location in the main salivary glands and to the diameter of the tumor. The strong expression of p53 and EGFR were bad prognostic factors. These retrospective results need to be confirmed by prospective randomized and larger studies. EGFR and p53 were significant negative prognostic factors. EGFR was highly correlated to the histological grade, making it an interesting target for further investigation.",
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AU - Aftimos, G.

AU - Sader-Ghorra, C.

AU - Sargi, Zoukaa B

AU - Haddad, A.

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N2 - Introduction: Mucoepidermoid carcinoma is one of the most frequent malignant lesions of salivary glands. The treatment is based on clinical, paraclinical and histological data. Several studies on the prognostic value of molecular markers for these cancers were made with contradictory results. The aim of this retrospective study was to analyze the prognostic value of molecular markers of salivary gland mucoepidermoid carcinoma. Material and methods: Sixteen patients were treated for mucoepidermoid carcinoma of principal and/or accessory salivary glands between 1994 and 2003. An immunohistochemical study of archive specimen was performed. Nine markers were specifically studied: 4 proteins/oncoproteins (p53, bcl2, c-erb-B2 and cd117), 2 markers of proliferation (PCNA and Ki67), 1 growing factor receptor (EGFR), 1 epithelial adhesion molecule (E-cadherin), and 1 angiogenic cytokine (PDGF). Results: Nine men and 7 women were included, with a mean age of 43.7 years (14-80). The mean diameter of tumors was 3.1 mm (1-14), and the parotid gland was the most frequent location. The mean global survival rate was 57.3 months with a median of 55 months. The 2 to 5 years survival expectation rate were 82.5% and 46.4% respectively. The mean survival rate for women was superior to that of men (P = 0.043). The expression of p53 and the high expression rate of EFGR were bad prognostic factors (respectively P = 0.049 and P = 0.012). The expression of PCNA was linked to the location (mainly the salivary gland) and to the diameter of the tumor (respectively P = 0.037 and P=0.029). The degree of EFGR positivity and the histological grade were linked (P = 0.027). Discussion: The strong expression of EGFR was statistically linked to the histological tumor grade. The degree of PCNA positivity seemed to be associated to the preferential location in the main salivary glands and to the diameter of the tumor. The strong expression of p53 and EGFR were bad prognostic factors. These retrospective results need to be confirmed by prospective randomized and larger studies. EGFR and p53 were significant negative prognostic factors. EGFR was highly correlated to the histological grade, making it an interesting target for further investigation.

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