Mucocutaneous pigmented macule as a result of zinc deposition

J. E. Greenberg, M. Lynn, Robert Kirsner, George Elgart, Andrew J. Hanly

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Mucocutaneous depositions of various metals such as silver, lead, gold, arsenic, mercury, iron, and bismuth have been previously published. Heavy metal deposition typically occurs in the setting of either prolonged topical application to intact skin, topical application to eroded or ulcerated skin, as a result of either parenteral administration, or due to penetrating traumatic exposure. Method: We report a unique case of mucocutaneous pigmentation occurring in a snow skier after topical application of a zinc-containing sunblock. Formalin-fixed paraffin-embedded tissue was utilized for electron microscopy. Result: Backscatter electron imaging and energy dispersive spectroscopy revealed that the dominant metal present was zinc. Conclusions: Mucocutaneous deposition of metals is enhanced by damage to the surface epithelium. Metal-containing topical agents, although commonly used, may rarely result in a permanent pigmentary alteration. We believe similar cases of mucocutaneous deposition of zinc exist; however, as these may be currently misdiagnosed as amalgam tattoos, the true incidence of this disorder is presently undefined.

Original languageEnglish
Pages (from-to)613-615
Number of pages3
JournalJournal of Cutaneous Pathology
Volume29
Issue number10
DOIs
StatePublished - Nov 1 2002

Fingerprint

Zinc
Metals
Snow
Skin
Bismuth
Pigmentation
Arsenic
Heavy Metals
Diagnostic Errors
Mercury
Silver
Gold
Paraffin
Formaldehyde
Spectrum Analysis
Electron Microscopy
Epithelium
Iron
Electrons
Incidence

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Mucocutaneous pigmented macule as a result of zinc deposition. / Greenberg, J. E.; Lynn, M.; Kirsner, Robert; Elgart, George; Hanly, Andrew J.

In: Journal of Cutaneous Pathology, Vol. 29, No. 10, 01.11.2002, p. 613-615.

Research output: Contribution to journalArticle

Greenberg, J. E. ; Lynn, M. ; Kirsner, Robert ; Elgart, George ; Hanly, Andrew J. / Mucocutaneous pigmented macule as a result of zinc deposition. In: Journal of Cutaneous Pathology. 2002 ; Vol. 29, No. 10. pp. 613-615.
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