Mu and delta receptors mediate morphine effects on phagocytosis by murine peritoneal macrophages

Nilka Tomassini, Fernando L. Renaud, Sabita Roy, Horace H. Loh

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Studies with selective opioid agonists show that μ- and δ2-opioid receptors, but not κ, are involved in opioid inhibition of phagocytosis in elicited murine macrophages. All μ and δ2 agonists tested had similar maximal effects on phagocytosis, and all dose-response curves suggest positive cooperativity. In addition, μ and δ antagonists antagonized the effect of both μ and δ agonists. Furthermore, in mu-opioid receptor knockout mice (MORKO), we observed a decrease in potency and maximal effect for a delta agonist. These data suggest that μ and δ receptors are not only involved in the modulation of phagocytosis in macrophages, but they also affect each other's activity by an unknown cooperative mechanism.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalJournal of Neuroimmunology
Volume136
Issue number1-2
DOIs
StatePublished - Mar 2003
Externally publishedYes

Keywords

  • Macrophages
  • Opioids
  • Phagocytosis
  • Receptors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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