MSH activity in plasma and pituitaries of rats with large hypothalamic lesions

A. J. Carrillo, A. J. Kastin, J. D. Dunn, A. V. Schally

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The effect of medial basal hypothalamic lesions on plasma and pituitary melanocyte stimulating hormone (MSH) was determined in albino rats. 32 days postoperatively, plasma levels of MSH were elevated (p<0.05) in female rats, whereas pituitary MSH activity was the same as in controls. Male rats also demonstrated elevated plasma MSH levels (p<0.05) when measured 23 days postoperatively. Histological evaluation of pituitaries from these animals revealed no changes in the intermediate lobe. These data suggest that MSH release from the pituitary of the albino rat is inhibited by central neural factors.

Original languageEnglish (US)
Pages (from-to)120-128
Number of pages9
Issue number2
StatePublished - 1973
Externally publishedYes


  • Intermediate lobe
  • MSH
  • Medial basal hypothalamus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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