MSH activity in plasma and pituitaries of rats with large hypothalamic lesions

A. J. Carrillo; A. J. Kastin; J. D. Dunn; A. V. Schally

doi:10.1159/000122161

MSH activity in plasma and pituitaries of rats with large hypothalamic lesions

A. J. Carrillo, A. J. Kastin, J. D. Dunn, A. V. Schally

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10 Scopus citations

Abstract

The effect of medial basal hypothalamic lesions on plasma and pituitary melanocyte stimulating hormone (MSH) was determined in albino rats. 32 days postoperatively, plasma levels of MSH were elevated (p<0.05) in female rats, whereas pituitary MSH activity was the same as in controls. Male rats also demonstrated elevated plasma MSH levels (p<0.05) when measured 23 days postoperatively. Histological evaluation of pituitaries from these animals revealed no changes in the intermediate lobe. These data suggest that MSH release from the pituitary of the albino rat is inhibited by central neural factors.

Original language	English (US)
Pages (from-to)	120-128
Number of pages	9
Journal	Neuroendocrinology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1159/000122161
State	Published - 1973
Externally published	Yes

Keywords

Intermediate lobe
MSH
Medial basal hypothalamus

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology
Endocrine and Autonomic Systems
Cellular and Molecular Neuroscience

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title = "MSH activity in plasma and pituitaries of rats with large hypothalamic lesions",

abstract = "The effect of medial basal hypothalamic lesions on plasma and pituitary melanocyte stimulating hormone (MSH) was determined in albino rats. 32 days postoperatively, plasma levels of MSH were elevated (p<0.05) in female rats, whereas pituitary MSH activity was the same as in controls. Male rats also demonstrated elevated plasma MSH levels (p<0.05) when measured 23 days postoperatively. Histological evaluation of pituitaries from these animals revealed no changes in the intermediate lobe. These data suggest that MSH release from the pituitary of the albino rat is inhibited by central neural factors.",

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year = "1973",

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AU - Kastin, A. J.

AU - Dunn, J. D.

AU - Schally, A. V.

PY - 1973

Y1 - 1973

N2 - The effect of medial basal hypothalamic lesions on plasma and pituitary melanocyte stimulating hormone (MSH) was determined in albino rats. 32 days postoperatively, plasma levels of MSH were elevated (p<0.05) in female rats, whereas pituitary MSH activity was the same as in controls. Male rats also demonstrated elevated plasma MSH levels (p<0.05) when measured 23 days postoperatively. Histological evaluation of pituitaries from these animals revealed no changes in the intermediate lobe. These data suggest that MSH release from the pituitary of the albino rat is inhibited by central neural factors.

AB - The effect of medial basal hypothalamic lesions on plasma and pituitary melanocyte stimulating hormone (MSH) was determined in albino rats. 32 days postoperatively, plasma levels of MSH were elevated (p<0.05) in female rats, whereas pituitary MSH activity was the same as in controls. Male rats also demonstrated elevated plasma MSH levels (p<0.05) when measured 23 days postoperatively. Histological evaluation of pituitaries from these animals revealed no changes in the intermediate lobe. These data suggest that MSH release from the pituitary of the albino rat is inhibited by central neural factors.

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KW - MSH

KW - Medial basal hypothalamus

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MSH activity in plasma and pituitaries of rats with large hypothalamic lesions

Abstract

Keywords

ASJC Scopus subject areas

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