MSH activity in pituitaries of rats exposed to stress

A. J. Kastin, A. Arimura, S. Viosca, L. Barrett, A. V. Schally

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Abstract

The stress of inhalation of ether for 1 min induced a significant decrease in levels of pituitary MSH, which occurred within a few minutes and persisted for 24 h. This MSH-depleting effect of ether was not blocked by pretreatmcnt with dexamcthasone or Nembutal. In addition, ether inhalation failed to prevent the elevation of pituitary MSH content after administration of MSH-release inhibiting factor (MIF). Whereas exposure to cold for 20 min decreased pituitary MSH levels, this effect was no longer evident at 24 h. The smell of blood, noise, starvation, and ip injection did not exert any consistent effect on pituitary MSH content. Several experimental conditions were found in which pituitary ACTH content did not change in parallel with pituitary MSH content.

Original languageEnglish (US)
Pages (from-to)200-208
Number of pages9
JournalNeuroendocrinology
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1967
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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