Abstract
Mesenchymal stromal cells (also often referred to as mesenchymal stem cells, MSCs) hold promise as a powerful tool in the treatment of human diseases. Because of their potent immunomodulatory properties, they are likely to impact in a positive fashion diseases in which inflammation and/or autoimmunity play a key role. Furthermore, they have been shown to possess plasticity as precursors of cells of various types. Their differentiation potential could span cell differentiation products that do not normally derive from the mesoderm, including cells of endodermal origin. These two remarkable features make them potentially ideal candidates for regenerative approaches. This chapter will briefly discuss the current state of the art in the emerging field of their use for autoimmune type 1 diabetes.
| Original language | English (US) |
|---|---|
| Title of host publication | Mesenchymal Stromal Cells |
| Subtitle of host publication | Biology and Clinical Applications |
| Publisher | Springer New York |
| Pages | 571-597 |
| Number of pages | 27 |
| ISBN (Electronic) | 9781461457114 |
| ISBN (Print) | 9781461457107 |
| DOIs | |
| State | Published - Jan 1 2013 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
MSCs for diabetes. / Inverardi, Luca A; Lanzoni, Giacomo; Dominguez-Bendala, Juan; Ricordi, Camillo.
Mesenchymal Stromal Cells: Biology and Clinical Applications. Springer New York, 2013. p. 571-597.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - MSCs for diabetes
AU - Inverardi, Luca A
AU - Lanzoni, Giacomo
AU - Dominguez-Bendala, Juan
AU - Ricordi, Camillo
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Mesenchymal stromal cells (also often referred to as mesenchymal stem cells, MSCs) hold promise as a powerful tool in the treatment of human diseases. Because of their potent immunomodulatory properties, they are likely to impact in a positive fashion diseases in which inflammation and/or autoimmunity play a key role. Furthermore, they have been shown to possess plasticity as precursors of cells of various types. Their differentiation potential could span cell differentiation products that do not normally derive from the mesoderm, including cells of endodermal origin. These two remarkable features make them potentially ideal candidates for regenerative approaches. This chapter will briefly discuss the current state of the art in the emerging field of their use for autoimmune type 1 diabetes.
AB - Mesenchymal stromal cells (also often referred to as mesenchymal stem cells, MSCs) hold promise as a powerful tool in the treatment of human diseases. Because of their potent immunomodulatory properties, they are likely to impact in a positive fashion diseases in which inflammation and/or autoimmunity play a key role. Furthermore, they have been shown to possess plasticity as precursors of cells of various types. Their differentiation potential could span cell differentiation products that do not normally derive from the mesoderm, including cells of endodermal origin. These two remarkable features make them potentially ideal candidates for regenerative approaches. This chapter will briefly discuss the current state of the art in the emerging field of their use for autoimmune type 1 diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85021671546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021671546&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-5711-4_33
DO - 10.1007/978-1-4614-5711-4_33
M3 - Chapter
AN - SCOPUS:85021671546
SN - 9781461457107
SP - 571
EP - 597
BT - Mesenchymal Stromal Cells
PB - Springer New York
ER -