MRI-negative frontal lobe epilepsy with ipsilateral akinesia and reflex activation

Stephen Malone, Ian Miller, Prasanna Jakayar, Trevor Resnick, Sanjiv Bhatia, Michael Duchowny

Research output: Contribution to journalArticle

5 Scopus citations


The preoperative assessment and surgical management of children and young adults with MRI-negative, frontal lobe epilepsy is often challenging owing to the semiologic expression being unusual or non-lateralizing. Localization based on functional tests may be non-convergent, further compounding the difficulty of surgical planning. We describe a patient with seizures presenting with early, subjective akinesia of the dominant hand that were at times triggered by repetitive motor tasks. Subdural EEG monitoring revealed seizure-origin in the ipsilateral dorsolateral frontal lobe. After resective surgery the patient has had a seizure free period of 9 months, and is free of deficits. This is the first report of frontal lobe seizure semiology consisting of ipsilateral ictal akinesia.

Original languageEnglish (US)
Pages (from-to)349-355
Number of pages7
JournalEpileptic Disorders
Issue number4
StatePublished - Dec 1 2008



  • Childhood epilepsy
  • Epilepsy surgery
  • Frontal lobe epilepsy
  • Presurgical assessment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Malone, S., Miller, I., Jakayar, P., Resnick, T., Bhatia, S., & Duchowny, M. (2008). MRI-negative frontal lobe epilepsy with ipsilateral akinesia and reflex activation. Epileptic Disorders, 10(4), 349-355.