MRI in experimental inflammatory and mitochondrial optic neuropathies

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

Original languageEnglish
Pages (from-to)968-977
Number of pages10
JournalNMR in Biomedicine
Volume21
Issue number9
DOIs
StatePublished - Dec 10 2008
Externally publishedYes

Fingerprint

Optic Nerve Diseases
Optic Nerve
Magnetic resonance imaging
Optics
Animals
Blood-Nerve Barrier
Autoimmune Experimental Encephalomyelitis
Electron Transport
Contrast Media
Blood
Animal Models
Imaging techniques
Enzymes

Keywords

  • Experimental autoimmune encephalomyelitis
  • Hereditary optic neuropathy
  • Multiple sclerosis
  • Optic neuritis

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

MRI in experimental inflammatory and mitochondrial optic neuropathies. / Guy, John.

In: NMR in Biomedicine, Vol. 21, No. 9, 10.12.2008, p. 968-977.

Research output: Contribution to journalArticle

@article{095e2018b5d84d60a44e7eb47e1522ed,
title = "MRI in experimental inflammatory and mitochondrial optic neuropathies",
abstract = "MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.",
keywords = "Experimental autoimmune encephalomyelitis, Hereditary optic neuropathy, Multiple sclerosis, Optic neuritis",
author = "John Guy",
year = "2008",
month = "12",
day = "10",
doi = "10.1002/nbm.1309",
language = "English",
volume = "21",
pages = "968--977",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "9",

}

TY - JOUR

T1 - MRI in experimental inflammatory and mitochondrial optic neuropathies

AU - Guy, John

PY - 2008/12/10

Y1 - 2008/12/10

N2 - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

AB - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

KW - Experimental autoimmune encephalomyelitis

KW - Hereditary optic neuropathy

KW - Multiple sclerosis

KW - Optic neuritis

UR - http://www.scopus.com/inward/record.url?scp=57149126851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57149126851&partnerID=8YFLogxK

U2 - 10.1002/nbm.1309

DO - 10.1002/nbm.1309

M3 - Article

C2 - 18756439

AN - SCOPUS:57149126851

VL - 21

SP - 968

EP - 977

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 9

ER -