Abstract
MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 968-977 |
| Number of pages | 10 |
| Journal | NMR in biomedicine |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| State | Published - Dec 10 2008 |
| Externally published | Yes |
Keywords
- Experimental autoimmune encephalomyelitis
- Hereditary optic neuropathy
- Multiple sclerosis
- Optic neuritis
ASJC Scopus subject areas
- Spectroscopy
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
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