Abstract
MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.
| Original language | English |
|---|---|
| Pages (from-to) | 968-977 |
| Number of pages | 10 |
| Journal | NMR in Biomedicine |
| Volume | 21 |
| Issue number | 9 |
| DOIs | |
| State | Published - Dec 10 2008 |
| Externally published | Yes |
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Keywords
- Experimental autoimmune encephalomyelitis
- Hereditary optic neuropathy
- Multiple sclerosis
- Optic neuritis
ASJC Scopus subject areas
- Spectroscopy
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
MRI in experimental inflammatory and mitochondrial optic neuropathies. / Guy, John.
In: NMR in Biomedicine, Vol. 21, No. 9, 10.12.2008, p. 968-977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MRI in experimental inflammatory and mitochondrial optic neuropathies
AU - Guy, John
PY - 2008/12/10
Y1 - 2008/12/10
N2 - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.
AB - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.
KW - Experimental autoimmune encephalomyelitis
KW - Hereditary optic neuropathy
KW - Multiple sclerosis
KW - Optic neuritis
UR - http://www.scopus.com/inward/record.url?scp=57149126851&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57149126851&partnerID=8YFLogxK
U2 - 10.1002/nbm.1309
DO - 10.1002/nbm.1309
M3 - Article
C2 - 18756439
AN - SCOPUS:57149126851
VL - 21
SP - 968
EP - 977
JO - NMR in Biomedicine
JF - NMR in Biomedicine
SN - 0952-3480
IS - 9
ER -