MRI in experimental inflammatory and mitochondrial optic neuropathies

John Guy

doi:10.1002/nbm.1309

MRI in experimental inflammatory and mitochondrial optic neuropathies

John Guy

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

Original language	English (US)
Pages (from-to)	968-977
Number of pages	10
Journal	NMR in biomedicine
Volume	21
Issue number	9
DOIs	https://doi.org/10.1002/nbm.1309
State	Published - Dec 10 2008
Externally published	Yes

Keywords

Experimental autoimmune encephalomyelitis
Hereditary optic neuropathy
Multiple sclerosis
Optic neuritis

ASJC Scopus subject areas

Spectroscopy
Molecular Medicine
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/nbm.1309

Cite this

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title = "MRI in experimental inflammatory and mitochondrial optic neuropathies",

abstract = "MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.",

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AU - Guy, John

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N2 - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

AB - MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI-histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood-optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes.

KW - Experimental autoimmune encephalomyelitis

KW - Hereditary optic neuropathy

KW - Multiple sclerosis

KW - Optic neuritis

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U2 - 10.1002/nbm.1309

DO - 10.1002/nbm.1309

M3 - Review article

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JO - NMR in Biomedicine

JF - NMR in Biomedicine

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ER -

MRI in experimental inflammatory and mitochondrial optic neuropathies

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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