MRI-Guided, noninvasive delivery of magneto-electric drug nanocarriers to the brain in a nonhuman primate

Ajeet Kaushik, Jose Rodriguez, Dan Rothen, Vinay Bhardwaj, Rahul Dev Jayant, Pradip Pattany, Beatriz Fuentes, Hitendra Chand, Nagesh Kolishetti, Nazira El-Hage, Kamel Khalili, Norma S. Kenyon, Madhavan Nair

Research output: Contribution to journalArticle

Abstract

A magnetically guided brain delivery method previously demonstrated in mice has not yet been translated for clinical applications due to the mismatch of available static magnet dimensions in relation to the human brain size and shape. To develop a human-compatible methodology, we explored magnetic resonance imaging (MRI) as a tool for the delivery of magneto-electric nanoparticles (MENPs) into the brain of a baboon, as a proof-of-concept study. MRI brain image analysis showed a reduction in T2∗ value at the basal ganglia, hemisphere, and vertex, thereby confirming successful MENP delivery to the brain. The observation of well-integrated morphologically healthy tissues and no blood toxicity over the study duration confirmed the biocompatibility of MENPs and the delivery procedure. Outcomes of this research present MRI-assisted delivery of MENPs to the brain as a safe and noninvasive method in larger species such as baboons and one step closer to human translation. This MENP-based nanomedicine delivery method can be used for clinical application in order to investigate effective central nervous system (CNS) therapies.

Original languageEnglish (US)
JournalACS Applied Bio Materials
DOIs
StateAccepted/In press - Jan 1 2019

    Fingerprint

Keywords

  • brain delivery
  • drug nanocarriers
  • magnetic resonance imaging (MRI)
  • magneto-electro nanoparticles (MENPs)
  • personalized nanomedicine

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Kaushik, A., Rodriguez, J., Rothen, D., Bhardwaj, V., Jayant, R. D., Pattany, P., Fuentes, B., Chand, H., Kolishetti, N., El-Hage, N., Khalili, K., Kenyon, N. S., & Nair, M. (Accepted/In press). MRI-Guided, noninvasive delivery of magneto-electric drug nanocarriers to the brain in a nonhuman primate. ACS Applied Bio Materials. https://doi.org/10.1021/acsabm.9b00592