MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD

Leyla DeToledo-Morrell, T. R. Stoub, M. Bulgakova, R. S. Wilson, D. A. Bennett, S. Leurgans, Joanne Wuu, D. A. Turner

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalNeurobiology of Aging
Volume25
Issue number9
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

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Alzheimer Disease
Magnetic Resonance Imaging
Entorhinal Cortex
Anatomy
Cognitive Dysfunction
Brain

Keywords

  • Aging
  • Hippocampal formation
  • Imaging
  • Memory
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

DeToledo-Morrell, L., Stoub, T. R., Bulgakova, M., Wilson, R. S., Bennett, D. A., Leurgans, S., ... Turner, D. A. (2004). MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of Aging, 25(9), 1197-1203. https://doi.org/10.1016/j.neurobiolaging.2003.12.007

MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. / DeToledo-Morrell, Leyla; Stoub, T. R.; Bulgakova, M.; Wilson, R. S.; Bennett, D. A.; Leurgans, S.; Wuu, Joanne; Turner, D. A.

In: Neurobiology of Aging, Vol. 25, No. 9, 01.10.2004, p. 1197-1203.

Research output: Contribution to journalArticle

DeToledo-Morrell, L, Stoub, TR, Bulgakova, M, Wilson, RS, Bennett, DA, Leurgans, S, Wuu, J & Turner, DA 2004, 'MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD', Neurobiology of Aging, vol. 25, no. 9, pp. 1197-1203. https://doi.org/10.1016/j.neurobiolaging.2003.12.007
DeToledo-Morrell L, Stoub TR, Bulgakova M, Wilson RS, Bennett DA, Leurgans S et al. MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of Aging. 2004 Oct 1;25(9):1197-1203. https://doi.org/10.1016/j.neurobiolaging.2003.12.007
DeToledo-Morrell, Leyla ; Stoub, T. R. ; Bulgakova, M. ; Wilson, R. S. ; Bennett, D. A. ; Leurgans, S. ; Wuu, Joanne ; Turner, D. A. / MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. In: Neurobiology of Aging. 2004 ; Vol. 25, No. 9. pp. 1197-1203.
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