MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD

Leyla DeToledo-Morrell, T. R. Stoub, M. Bulgakova, R. S. Wilson, D. A. Bennett, S. Leurgans, J. Wuu, D. A. Turner

Research output: Contribution to journalArticle

244 Scopus citations

Abstract

With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%.

Original languageEnglish (US)
Pages (from-to)1197-1203
Number of pages7
JournalNeurobiology of aging
Volume25
Issue number9
DOIs
StatePublished - Oct 1 2004
Externally publishedYes

Keywords

  • Aging
  • Hippocampal formation
  • Imaging
  • Memory
  • Temporal lobe

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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    DeToledo-Morrell, L., Stoub, T. R., Bulgakova, M., Wilson, R. S., Bennett, D. A., Leurgans, S., Wuu, J., & Turner, D. A. (2004). MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of aging, 25(9), 1197-1203. https://doi.org/10.1016/j.neurobiolaging.2003.12.007