MRI-based noninvasive measurement of intracranial compliance derived from the relationship between transcranial blood and cerebrospinal fluid flows: Modeling vs. direct approach

Rong Wen Tain, Noam Alperin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Intracranial compliance (ICC) determines the ability of the intracranial space to accommodate increase in volume (e.g., brain swelling) without a large increase in intracranial pressure (ICP). Therefore, measurement of ICC is potentially important for diagnosis and guiding treatment of related neurological problems. Modeling based approach uses an assumed lumped-parameter model of the craniospinal system (CSS) (e.g., RCL circuit), with either the arterial6,7 or the net transcranial blood flow1 (arterial inflow minus venous outflow) as input and the cranio-spinal cerebrospinal fluid (CSF) flow as output. The phase difference between the output and input is then often used as a measure of ICC4,6,7,11. However, it is not clear whether there is a predetermined relationship between ICC and the phase difference between these waveforms. A different approach for estimation of ICC has been recently proposed2. This approach estimates ICC from the ratio of the intracranial volume and pressure changes that occur naturally with each heartbeat. The current study evaluates the sensitivity of the phase-based and the direct approach to changes in ICC. An RLC circuit model of the cranio-spinal system is used to simulate the cranio-spinal CSF flow for 3 different ICC states using the transcranial blood flows measured by MRI phase contrast from healthy human subjects. The effect of the increase in the ICC on the magnitude and phase response is calculated from the system's transfer function. We observed that within the heart rate frequency range, changes in ICC predominantly affected the amplitude of CSF pulsation and less so the phases. The compliance is then obtained for the different ICC states using the direct approach. The measures of compliance calculated using the direct approach demonstrated the highest sensitivity for changes in ICC This work explains why phase shift based measure of ICC is less sensitive than amplitude based measures such as the direct approach method2.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
DOIs
StatePublished - Jun 2 2008
Externally publishedYes
EventMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images - San Diego, CA, United States
Duration: Feb 17 2008Feb 19 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6916
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2008 - Physiology, Function, and Structure from Medical Images
CountryUnited States
CitySan Diego, CA
Period2/17/082/19/08

Keywords

  • Cerebrospinal fluid flow
  • Craniospinal system
  • Intracranial compliance

ASJC Scopus subject areas

  • Engineering(all)

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    Tain, R. W., & Alperin, N. (2008). MRI-based noninvasive measurement of intracranial compliance derived from the relationship between transcranial blood and cerebrospinal fluid flows: Modeling vs. direct approach. In Medical Imaging 2008 - Physiology, Function, and Structure from Medical Images [691610] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6916). https://doi.org/10.1117/12.770851