MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics

Shota Ishida, Tosiaki Miyati, Naoki Ohno, Shinnosuke Hiratsuka, Noam Alperin, Mitsuhito Mase, Toshifumi Gabata

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
DOIs
StateAccepted/In press - 2017

Fingerprint

Head-Down Tilt
Hydrodynamics
Hemodynamics
Jugular Veins
Blood Flow Velocity
Cerebrospinal Fluid
Brain
Cerebrospinal Fluid Pressure
Spinal Canal
Venous Pressure
Intracranial Hypertension
Supine Position
Internal Carotid Artery
Nonparametric Statistics
Posture
Skull
Compliance
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • Brain morphology
  • Cerebral hemodynamics
  • Cerebrospinal fluid pressure gradient
  • Head-down tilt
  • Intracranial physiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics. / Ishida, Shota; Miyati, Tosiaki; Ohno, Naoki; Hiratsuka, Shinnosuke; Alperin, Noam; Mase, Mitsuhito; Gabata, Toshifumi.

In: Journal of Magnetic Resonance Imaging, 2017.

Research output: Contribution to journalArticle

Ishida, Shota ; Miyati, Tosiaki ; Ohno, Naoki ; Hiratsuka, Shinnosuke ; Alperin, Noam ; Mase, Mitsuhito ; Gabata, Toshifumi. / MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics. In: Journal of Magnetic Resonance Imaging. 2017.
@article{10d0091d4baa42fba832c47311e6e6be,
title = "MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics",
abstract = "Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.",
keywords = "Brain morphology, Cerebral hemodynamics, Cerebrospinal fluid pressure gradient, Head-down tilt, Intracranial physiology",
author = "Shota Ishida and Tosiaki Miyati and Naoki Ohno and Shinnosuke Hiratsuka and Noam Alperin and Mitsuhito Mase and Toshifumi Gabata",
year = "2017",
doi = "10.1002/jmri.25781",
language = "English (US)",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics

AU - Ishida, Shota

AU - Miyati, Tosiaki

AU - Ohno, Naoki

AU - Hiratsuka, Shinnosuke

AU - Alperin, Noam

AU - Mase, Mitsuhito

AU - Gabata, Toshifumi

PY - 2017

Y1 - 2017

N2 - Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.

AB - Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.

KW - Brain morphology

KW - Cerebral hemodynamics

KW - Cerebrospinal fluid pressure gradient

KW - Head-down tilt

KW - Intracranial physiology

UR - http://www.scopus.com/inward/record.url?scp=85020104337&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020104337&partnerID=8YFLogxK

U2 - 10.1002/jmri.25781

DO - 10.1002/jmri.25781

M3 - Article

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

ER -