Abstract
Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.
| Original language | English (US) |
|---|---|
| Journal | Journal of Magnetic Resonance Imaging |
| DOIs | |
| State | Accepted/In press - 2017 |
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Keywords
- Brain morphology
- Cerebral hemodynamics
- Cerebrospinal fluid pressure gradient
- Head-down tilt
- Intracranial physiology
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics. / Ishida, Shota; Miyati, Tosiaki; Ohno, Naoki; Hiratsuka, Shinnosuke; Alperin, Noam; Mase, Mitsuhito; Gabata, Toshifumi.
In: Journal of Magnetic Resonance Imaging, 2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - MRI-based assessment of acute effect of head-down tilt position on intracranial hemodynamics and hydrodynamics
AU - Ishida, Shota
AU - Miyati, Tosiaki
AU - Ohno, Naoki
AU - Hiratsuka, Shinnosuke
AU - Alperin, Noam
AU - Mase, Mitsuhito
AU - Gabata, Toshifumi
PY - 2017
Y1 - 2017
N2 - Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.
AB - Purpose: To quantify the acute effect of the head-down tilt (HDT) posture on intracranial hemodynamics and hydrodynamics. Materials and Methods: We evaluated the intracranial physiological parameters, blood flow-related parameters, and brain morphology in the HDT (-6° and -12°) and the horizontal supine (HS) positions. Seven and 15 healthy subjects were scanned for each position using 3.0 T magnetic resonance imaging system. The peak-to-peak intracranial volume change, the peak-to-peak cerebrospinal fluid (CSF) pressure gradient (PGp-p), and the intracranial compliance index were calculated from the blood and CSF flow determined using a cine phase-contrast technique. The brain volumetry was conducted using SPM12. The measurements were compared using the Wilcoxon signed-rank test or a paired t-test. Results: No measurements changed in the -6° HDT. The PGp-p and venous outflow of the internal jugular veins (IJVs) in the -12° HDT were significantly increased compared to the HS (P < 0.001 and P = 0.025, respectively). The cross-sectional areas of the IJVs were significantly larger (P < 0.001), and the maximum, minimum, and mean blood flow velocity of the IJVs were significantly decreased (P = 0.003, < 0.001, and = 0.001, respectively) in the -12° HDT. The mean blood flow velocities of the internal carotid arteries were decreased (P = 0.023). Neither position affected the brain volume. Conclusion: Pressure gradient and venous outflow were increased in accordance with the elevation of the intracranial pressure as an acute effect of the HDT. However, the CSF was not constantly shifted from the spinal canal to the cranium.
KW - Brain morphology
KW - Cerebral hemodynamics
KW - Cerebrospinal fluid pressure gradient
KW - Head-down tilt
KW - Intracranial physiology
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U2 - 10.1002/jmri.25781
DO - 10.1002/jmri.25781
M3 - Article
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
ER -