MR susceptometry: an external‐phantom method for measuring bulk susceptibility from field‐echo phase reconstruction maps

Randall W. Holt, Pedro J. Diaz, Jeffrey L. Duerk, Errol M. Bellon

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

A novel method for estimating the susceptibility of an object by using the magnetic resonance (MR) imaging field distortions in an external‐reference water bath next to the object is described. The field measurement was obtained with a phase reconstruction from a gradient‐echo acquisition. A field model of an arbitrary object in a static magnetic field was discretely calculated from geometry determined from the magnitude reconstruction. Least‐squares estimation yields the susceptibility of the object. Required (and proven) assumptions include validity of superposition, object homogeneity, negligible higher‐order field terms, field‐model accuracy, geometric‐model accuracy, and correlation of gradient‐echo phase to field distortion. MR susceptometry estimation of phantoms yielded susceptibility estimates that correlated well with known values (r >.9975). This MR susceptometry method is a first step toward quantitation of iron levels through MR imaging phase information in patients with iron overload.

Original languageEnglish (US)
Pages (from-to)809-818
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume4
Issue number6
DOIs
StatePublished - 1994
Externally publishedYes

Keywords

  • Iron
  • Liver, iron content, 761.121412
  • Liver, MR, 761.121412
  • Susceptibility studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'MR susceptometry: an external‐phantom method for measuring bulk susceptibility from field‐echo phase reconstruction maps'. Together they form a unique fingerprint.

Cite this