Mr microscopy of the arterial wall in an experimental model of atherosclerosis

Preliminary results

John Ford, Richard D. Shlansky-Goldberg, Michael Golden

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

PURPOSE: To obtain images of the arterial lumen and wall in a rabbit model of atherosclerosis with use of high-resolution magnetic resonance (MR) imaging to follow morphologic changes during the induction of atherosclerosis and, hence, develop a noninvasive tool to investigate restenosis. MATERIALS AND METHODS: In vivo microscopic MR images of rabbit aorta were acquired after balloon injury. Measurements of wall and lumen diameter from MR images area were compared with measurements obtained from histologic and angiographic examination. RESULTS: Injured rabbits exhibited an obvious thickening of the arterial wall, accompanied by an increased wall conspicuity, probably due to increases in T2. Quantitative MR morphometry corresponded well with morphologic measurements based on angiographic and histologic study. CONCLUSIONS: MR implanted coil technology affords imaging of the arterial lumen and wall, allowing temporal assessment of the morphologic changes due to intimal hyperplasia after balloon dilation and may enable the evaluation of novel techniques to eliminate restenosis.

Original languageEnglish (US)
Pages (from-to)93-99
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Volume8
Issue number1
StatePublished - Jan 1997
Externally publishedYes

Fingerprint

Microscopy
Atherosclerosis
Theoretical Models
Magnetic Resonance Spectroscopy
Rabbits
Tunica Intima
Hyperplasia
Aorta
Dilatation
Magnetic Resonance Imaging
Technology
Wounds and Injuries

Keywords

  • Arteriosclerosis
  • Magnetic resonance (MR)
  • Regular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Mr microscopy of the arterial wall in an experimental model of atherosclerosis : Preliminary results. / Ford, John; Shlansky-Goldberg, Richard D.; Golden, Michael.

In: Journal of Vascular and Interventional Radiology, Vol. 8, No. 1, 01.1997, p. 93-99.

Research output: Contribution to journalArticle

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