MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system

Elmar M. Merkle, John R. Haaga, Jeffrey L. Duerk, Gretta H. Jacobs, Hans Juergen Brambs, Jonathan S. Lewin

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


PURPOSE: To test the hypotheses that (a) magnetic resonance (MR) imaging-guided radio-frequency (RF) thermal ablation in the pancreas is safe and feasible in a porcine model and (b) induced thermal lesion size can be predicted with MR imaging monitoring. MATERIALS AND METHODS: MR imaging- guided RF ablation was performed in the pancreas of six pigs. A 17-gauge monopolar RF probe was inserted into the pancreas with MR imaging guidance, and RF was applied for 10 minutes. After postprocedural imaging (T2-weighted, short inversion time inversion-recovery [STIR], and T1-weighted imaging before and after intravenous administration of gadodiamide), the pigs were observed for 7 days and follow-up MR images were acquired. The pigs were sacrificed, and pathologic examination was performed. RESULTS: Successful RF probe placement was accomplished in all pigs; the interventional procedure took 46-80 minutes. Thermal lesions were 12-15 mm perpendicular to the probe track and were best seen on STIR and contrast material-enhanced T1-weighted images with a radiologic and/or pathologic mean difference in RF lesion diameter of 1.7 mm ± 1.0 (SD) and 0.8 mm ± 1.2, respectively. Diarrhea was the only side effect during the 1-week follow-up; no clinical signs of pancreatitis occurred. CONCLUSION: MR imaging-guided RF thermal ablation in the pancreas is feasible and safe. Induced thermal lesion size can best be monitored with STIR and contrast-enhanced T1-weighted images. In the future, RF ablation may offer an alternative treatment option for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
Issue number2
StatePublished - Nov 1999
Externally publishedYes


  • Interventional procedures, experimental studies
  • Magnetic resonance (MR), guidance
  • Pancreas, interventional procedures
  • Pancreatitis
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'MR imaging-guided radio-frequency thermal ablation in the pancreas in a porcine model with a modified clinical C-arm system'. Together they form a unique fingerprint.

Cite this