MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis

Brian C. Bowen, Pradip Pattany, Walter G Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan, Robert Quencer

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE: In the search for a diagnostic test for amyotrophic lateral sclerosis (ALS), especially upper motor neuron (UMN) involvement, MR imaging and proton spectroscopy techniques have each received attention, but their findings have not been correlated. The purpose of this study was to identify relationships among the results of current techniques, taking into account the severity of clinical UMN disease, so that objective measures of the pathogenesis of ALS may be established. METHODS: Eighteen subjects with clinically diagnosed ALS and 12 healthy volunteers underwent MR imaging of the brain and localized proton MR spectroscopy. Water-suppressed spectra from the left precentral gyrus and from the left cuneus gyrus were analyzed with the LCModel method, yielding concentrations for N-acetyl (NA), total creatine (Cr), choline (Cho), glutamate (Glu), glutamine (Gln), and myo-inositol (Ins) metabolic substrates. Signal intensities of the precentral gyrus on T2-weighted images were assessed qualitatively in a blinded fashion. RESULTS: For the precentral gyrus, mean Cho (1.3 mM) and Ins (3.25 mM) for the ALS group were significantly increased. After adjustment for Cr covariance, mean Glu (5.08 mM) and NA (6.31 mM) were decreased. For the cuneus gyrus, no difference in metabolite concentrations between groups was observed. Trend analysis of the precentral gyrus metabolite concentrations revealed significant increases in Cho and Ins and decreases in NA and Glu with respect to the severity of clinical UMN signs. Metabolic changes were greater in the subset of ALS patients with precentral gyrus signal changes on imaging, and significantly increased Ins was associated with cortical hypointensity on fast spin-echo images. CONCLUSION: Mean metabolite concentrations determined from precentral gyms spectra reflect clinical and pathologic changes that occur in ALS. Imaging findings, while related to the spectral and clinical results, are not specific to ALS.

Original languageEnglish
Pages (from-to)647-658
Number of pages12
JournalAmerican Journal of Neuroradiology
Volume21
Issue number4
StatePublished - Apr 1 2000

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Amyotrophic Lateral Sclerosis
Frontal Lobe
Protons
Spectrum Analysis
Inositol
Choline
Glutamic Acid
Occipital Lobe
Creatine
Motor Neurons
Motor Neuron Disease
Glutamine
Routine Diagnostic Tests
Neuroimaging
Healthy Volunteers
Magnetic Resonance Spectroscopy
Water

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. / Bowen, Brian C.; Pattany, Pradip; Bradley, Walter G; Murdoch, James B.; Rotta, Francisco; Younis, Akmal A.; Duncan, Robert C.; Quencer, Robert.

In: American Journal of Neuroradiology, Vol. 21, No. 4, 01.04.2000, p. 647-658.

Research output: Contribution to journalArticle

Bowen, Brian C. ; Pattany, Pradip ; Bradley, Walter G ; Murdoch, James B. ; Rotta, Francisco ; Younis, Akmal A. ; Duncan, Robert C. ; Quencer, Robert. / MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. In: American Journal of Neuroradiology. 2000 ; Vol. 21, No. 4. pp. 647-658.
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AU - Pattany, Pradip

AU - Bradley, Walter G

AU - Murdoch, James B.

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AU - Younis, Akmal A.

AU - Duncan, Robert C.

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