MR characterization of brain and brain tumor response to radiotherapy

Pavel V. Houdek, Howard Landy, Robert Quencer, William Sattin, Catherine A. Poole, Barth A Green, Claude A. Harmon, Vincent Pisciotta, James G. Schwade

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This paper describes our experience in using the T1 and T2 relaxation times for quantitative evaluation of brain and brain tumor response to radiation therapy. Twenty-two computed T1 and 22 computed T2 images were obtained from 66 routine inversion-recovery and spin-echo magnetic resonance (MR) brain scans. The relaxation times of the brain tissues, determined from the computed images, were examined as a function of the absorbed dose. Statistical evaluation of the results showed no significant difference between the relaxation times of irradiated and not irradiated tissues, including tumor and normal white matter. Influence of the magnetic field strength and imaging techniques on the computed T1 and T2 values was confirmed. We conclude that the relaxation time values, as obtained today using conventional MR scanner and standard software, are not specific enough to warrant a correct assessment of the acute radiation effect on the brain tissues.

Original languageEnglish
Pages (from-to)213-218
Number of pages6
JournalInternational journal of radiation oncology, biology, physics
Volume15
Issue number1
DOIs
StatePublished - Jan 1 1988

Fingerprint

Brain Neoplasms
brain
magnetic resonance
radiation therapy
Magnetic Resonance Spectroscopy
Radiotherapy
tumors
relaxation time
Brain
Radiation Effects
Magnetic Fields
evaluation
radiation effects
Software
imaging techniques
scanners
field strength
echoes
recovery
inversions

Keywords

  • Brain radiotherapy
  • Magnetic resonance
  • Quality control

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

MR characterization of brain and brain tumor response to radiotherapy. / Houdek, Pavel V.; Landy, Howard; Quencer, Robert; Sattin, William; Poole, Catherine A.; Green, Barth A; Harmon, Claude A.; Pisciotta, Vincent; Schwade, James G.

In: International journal of radiation oncology, biology, physics, Vol. 15, No. 1, 01.01.1988, p. 213-218.

Research output: Contribution to journalArticle

Houdek, Pavel V. ; Landy, Howard ; Quencer, Robert ; Sattin, William ; Poole, Catherine A. ; Green, Barth A ; Harmon, Claude A. ; Pisciotta, Vincent ; Schwade, James G. / MR characterization of brain and brain tumor response to radiotherapy. In: International journal of radiation oncology, biology, physics. 1988 ; Vol. 15, No. 1. pp. 213-218.
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