MR characterization of brain and brain tumor response to radiotherapy

Pavel V. Houdek, Howard J. Landy, Robert M. Quencer, William Sattin, Catherine A. Poole, Barth A. Green, Claude A. Harmon, Vincent Pisciotta, James G. Schwade

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This paper describes our experience in using the T1 and T2 relaxation times for quantitative evaluation of brain and brain tumor response to radiation therapy. Twenty-two computed T1 and 22 computed T2 images were obtained from 66 routine inversion-recovery and spin-echo magnetic resonance (MR) brain scans. The relaxation times of the brain tissues, determined from the computed images, were examined as a function of the absorbed dose. Statistical evaluation of the results showed no significant difference between the relaxation times of irradiated and not irradiated tissues, including tumor and normal white matter. Influence of the magnetic field strength and imaging techniques on the computed T1 and T2 values was confirmed. We conclude that the relaxation time values, as obtained today using conventional MR scanner and standard software, are not specific enough to warrant a correct assessment of the acute radiation effect on the brain tissues.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalInternational Journal of Radiation Oncology, Biology, Physics
Issue number1
StatePublished - Jul 1988


  • Brain radiotherapy
  • Magnetic resonance
  • Quality control

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation


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