Movement Disorders: Tics and Tourette's Disorder

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tourette's disorder (TD) is a complex neuropsychiatric disorder with a heterogeneous phenotype characterized by core disinhibition mediated by the cortico-striato-thalamo-cortical tracts. TD is genetically determined in most cases. There is a growing appreciation and understanding of the role of psychiatric comorbidity in the diverse clinical presentation and impact on quality of life in those affected. Treatment strategies should be multimodal in nature, and include pharmacotherapy and, where indicated, behavior, individual, and family intervention and educational monitoring. Prospective longitudinal studies and randomized clinical trials have advanced our understanding of several models of pathogenesis and the evidence base regarding novel treatment options. However, further investigation is needed to better understand the phenomenology, developmental psychopathology, and treatment of this complex disorder. This chapter reviews the following: classification and clinical phenomenology, clinical course, psychiatric comorbidity, genetic findings, etiology, and pathophysiology, pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS), differential diagnosis, clinical evaluation, and treatment of Tourette's disorder.

Original languageEnglish (US)
Title of host publicationClinical Child Psychiatry, Third Edition
PublisherJohn Wiley and Sons
Pages399-417
Number of pages19
ISBN (Print)9781119993346
DOIs
StatePublished - Mar 30 2012
Externally publishedYes

Keywords

  • Attention-deficit hyperactivity disorder
  • Comorbidity
  • Obsessive-compulsive disorder
  • Psychopharmacological treatment
  • Tics
  • Tourette's disorder

ASJC Scopus subject areas

  • Medicine(all)

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