Abstract
Despite years of intensive research, the understanding of Parkinson's disease (PD) is still rudimentary. Genetic causes of rare familial cases have offered venues of investigation, and interestingly, have strengthened the case for a mitochondrial dysfunction in the pathogenesis of PD. Mouse models, where these and other mitochondrial-related genes are affected are helping not only in understanding PD, but also in providing a powerful tool to test therapeutics. In this review, we will discuss the different characteristics of these mouse models. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
| Original language | English |
|---|---|
| Pages (from-to) | 87-94 |
| Number of pages | 8 |
| Journal | Molecular and Cellular Neuroscience |
| Volume | 55 |
| DOIs | |
| State | Published - Jul 1 2013 |
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Keywords
- Mitochondria
- Parkinson's disease
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
- Cell Biology
Cite this
Mouse models of Parkinson's disease associated with mitochondrial dysfunction. / Pickrell, Alicia M.; Pinto, Milena; Moraes, Carlos T.
In: Molecular and Cellular Neuroscience, Vol. 55, 01.07.2013, p. 87-94.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mouse models of Parkinson's disease associated with mitochondrial dysfunction
AU - Pickrell, Alicia M.
AU - Pinto, Milena
AU - Moraes, Carlos T
PY - 2013/7/1
Y1 - 2013/7/1
N2 - Despite years of intensive research, the understanding of Parkinson's disease (PD) is still rudimentary. Genetic causes of rare familial cases have offered venues of investigation, and interestingly, have strengthened the case for a mitochondrial dysfunction in the pathogenesis of PD. Mouse models, where these and other mitochondrial-related genes are affected are helping not only in understanding PD, but also in providing a powerful tool to test therapeutics. In this review, we will discuss the different characteristics of these mouse models. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
AB - Despite years of intensive research, the understanding of Parkinson's disease (PD) is still rudimentary. Genetic causes of rare familial cases have offered venues of investigation, and interestingly, have strengthened the case for a mitochondrial dysfunction in the pathogenesis of PD. Mouse models, where these and other mitochondrial-related genes are affected are helping not only in understanding PD, but also in providing a powerful tool to test therapeutics. In this review, we will discuss the different characteristics of these mouse models. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.
KW - Mitochondria
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=84875597097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875597097&partnerID=8YFLogxK
U2 - 10.1016/j.mcn.2012.08.002
DO - 10.1016/j.mcn.2012.08.002
M3 - Article
VL - 55
SP - 87
EP - 94
JO - Molecular and Cellular Neuroscience
JF - Molecular and Cellular Neuroscience
SN - 1044-7431
ER -