Mouse models of cancer as biological filters for complex genomic data

Elisa Oricchio, Andrew L. Wolfe, Jonathan H Schatz, Konstantinos J. Mavrakis, Hans Guido Wendel

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Genetically and pathologically accurate mouse models of leukemia and lymphoma have been developed in recent years. Adoptive transfer of genetically modified hematopoietic progenitor cells enables rapid and highly controlled gain- and loss-of-function studies for these types of cancer. In this Commentary, we discuss how these highly versatile experimental approaches can be used as biological filters to pinpoint transformation-relevant activities from complex cancer genome data. We anticipate that the functional identification of genetic 'drivers' using mouse models of leukemia and lymphoma will facilitate the development of molecular diagnostics and mechanism-based therapies for patients that suffer from these diseases.

Original languageEnglish (US)
Pages (from-to)701-704
Number of pages4
JournalDMM Disease Models and Mechanisms
Volume3
Issue number11-12
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Lymphoma
Leukemia
Molecular Pathology
Adoptive Transfer
Hematopoietic Stem Cells
Neoplasms
Identification (control systems)
Genes
Genome
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • Neuroscience (miscellaneous)

Cite this

Mouse models of cancer as biological filters for complex genomic data. / Oricchio, Elisa; Wolfe, Andrew L.; Schatz, Jonathan H; Mavrakis, Konstantinos J.; Wendel, Hans Guido.

In: DMM Disease Models and Mechanisms, Vol. 3, No. 11-12, 11.2010, p. 701-704.

Research output: Contribution to journalArticle

Oricchio, Elisa ; Wolfe, Andrew L. ; Schatz, Jonathan H ; Mavrakis, Konstantinos J. ; Wendel, Hans Guido. / Mouse models of cancer as biological filters for complex genomic data. In: DMM Disease Models and Mechanisms. 2010 ; Vol. 3, No. 11-12. pp. 701-704.
@article{e25e318c568f406d9c4bba55e2071da0,
title = "Mouse models of cancer as biological filters for complex genomic data",
abstract = "Genetically and pathologically accurate mouse models of leukemia and lymphoma have been developed in recent years. Adoptive transfer of genetically modified hematopoietic progenitor cells enables rapid and highly controlled gain- and loss-of-function studies for these types of cancer. In this Commentary, we discuss how these highly versatile experimental approaches can be used as biological filters to pinpoint transformation-relevant activities from complex cancer genome data. We anticipate that the functional identification of genetic 'drivers' using mouse models of leukemia and lymphoma will facilitate the development of molecular diagnostics and mechanism-based therapies for patients that suffer from these diseases.",
author = "Elisa Oricchio and Wolfe, {Andrew L.} and Schatz, {Jonathan H} and Mavrakis, {Konstantinos J.} and Wendel, {Hans Guido}",
year = "2010",
month = "11",
doi = "10.1242/dmm.006296",
language = "English (US)",
volume = "3",
pages = "701--704",
journal = "DMM Disease Models and Mechanisms",
issn = "1754-8403",
publisher = "Company of Biologists Ltd",
number = "11-12",

}

TY - JOUR

T1 - Mouse models of cancer as biological filters for complex genomic data

AU - Oricchio, Elisa

AU - Wolfe, Andrew L.

AU - Schatz, Jonathan H

AU - Mavrakis, Konstantinos J.

AU - Wendel, Hans Guido

PY - 2010/11

Y1 - 2010/11

N2 - Genetically and pathologically accurate mouse models of leukemia and lymphoma have been developed in recent years. Adoptive transfer of genetically modified hematopoietic progenitor cells enables rapid and highly controlled gain- and loss-of-function studies for these types of cancer. In this Commentary, we discuss how these highly versatile experimental approaches can be used as biological filters to pinpoint transformation-relevant activities from complex cancer genome data. We anticipate that the functional identification of genetic 'drivers' using mouse models of leukemia and lymphoma will facilitate the development of molecular diagnostics and mechanism-based therapies for patients that suffer from these diseases.

AB - Genetically and pathologically accurate mouse models of leukemia and lymphoma have been developed in recent years. Adoptive transfer of genetically modified hematopoietic progenitor cells enables rapid and highly controlled gain- and loss-of-function studies for these types of cancer. In this Commentary, we discuss how these highly versatile experimental approaches can be used as biological filters to pinpoint transformation-relevant activities from complex cancer genome data. We anticipate that the functional identification of genetic 'drivers' using mouse models of leukemia and lymphoma will facilitate the development of molecular diagnostics and mechanism-based therapies for patients that suffer from these diseases.

UR - http://www.scopus.com/inward/record.url?scp=78649279352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649279352&partnerID=8YFLogxK

U2 - 10.1242/dmm.006296

DO - 10.1242/dmm.006296

M3 - Article

C2 - 20876355

AN - SCOPUS:78649279352

VL - 3

SP - 701

EP - 704

JO - DMM Disease Models and Mechanisms

JF - DMM Disease Models and Mechanisms

SN - 1754-8403

IS - 11-12

ER -