Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model

Amos Gilhar, Rimma Laufer Britva, Aviad Keren, Ralf Paus

Research output: Contribution to journalReview articlepeer-review

Abstract

The C3H/HeJ model has long dominated basic alopecia areata (AA) in vivo research and has been used as proof-of-principle that Jak inhibitors are suitable agents for AA management in vivo. However, its histologic features are not typical of human AA, and it is questionable whether it is sufficiently clinically predictive for evaluating the therapeutic effects of candidate AA agents. Instead, the humanized mouse model of AA has been used to functionally demonstrate the role of key immune cells in AA pathogenesis and to discover human-specific pharmacologic targets in AA management. Therefore, we advocate the use of both models in future preclinical AA research.

Original languageEnglish (US)
Pages (from-to)S11-S15
JournalJournal of Investigative Dermatology Symposium Proceedings
Volume20
Issue number1
DOIs
StatePublished - Nov 2020

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Dermatology
  • Cell Biology

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